Open Access

Interplay between lncRNAs and the PI3K/AKT signaling pathway in the progression of digestive system neoplasms (Review)

  • Authors:
    • Xiaoyu Zhang
    • Lei Shi
    • Mengzhen Xing
    • Chunjing Li
    • Fengjun Ma
    • Yuning Ma
    • Yuxia Ma
  • View Affiliations

  • Published online on: November 7, 2024     https://doi.org/10.3892/ijmm.2024.5456
  • Article Number: 15
  • Copyright: © Zhang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Long non‑coding RNA (lncRNA) is a class of non‑coding RNA molecules located in the cytoplasm or nucleus, which can regulate chromosome structure and function by interacting with DNA, RNA, proteins and other molecules; binding to mRNA bases in a complementary manner, affecting the splicing, stabilization, translation and degradation of mRNA; acting as competing endogenous RNA competitively binds to microRNAs to regulate gene expression and participate in the regulation of various vital activities of the body. The PI3K/AKT signalling pathway plays a key role in numerous biological and cellular processes, such as cell proliferation, invasion, migration and angiogenesis. It has been found that the lncRNA/PI3K/AKT axis regulates the expression of cancer‑related genes and thus tumour progression. The abnormal regulation of lncRNA expression in the lncRNA/PI3K/AKT axis is clearly associated with clinicopathological features and plays an important role in regulating biological functions. In the present review, the expression and biological functions of PI3K/AKT‑related lncRNAs both in vitro and in vivo over recent years, were comprehensively summarized and analyzed. Their correlation with clinicopathological features was also evaluated, with the objective of furnishing a solid theoretical foundation for clinical diagnosis and the monitoring of efficacy in digestive system neoplasms. The present review aimed to provide a comprehensive overview of the expression and biological functions of PI3K/AKT‑related lncRNAs in digestive system neoplasms and to assess their correlation with clinicopathological features. This endeavor seeks to establish a solid theoretical foundation for the clinical diagnosis and efficacy monitoring of digestive system tumors.
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January-2025
Volume 55 Issue 1

Print ISSN: 1107-3756
Online ISSN:1791-244X

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Copy and paste a formatted citation
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Spandidos Publications style
Zhang X, Shi L, Xing M, Li C, Ma F, Ma Y and Ma Y: Interplay between lncRNAs and the PI3K/AKT signaling pathway in the progression of digestive system neoplasms (Review). Int J Mol Med 55: 15, 2025.
APA
Zhang, X., Shi, L., Xing, M., Li, C., Ma, F., Ma, Y., & Ma, Y. (2025). Interplay between lncRNAs and the PI3K/AKT signaling pathway in the progression of digestive system neoplasms (Review). International Journal of Molecular Medicine, 55, 15. https://doi.org/10.3892/ijmm.2024.5456
MLA
Zhang, X., Shi, L., Xing, M., Li, C., Ma, F., Ma, Y., Ma, Y."Interplay between lncRNAs and the PI3K/AKT signaling pathway in the progression of digestive system neoplasms (Review)". International Journal of Molecular Medicine 55.1 (2025): 15.
Chicago
Zhang, X., Shi, L., Xing, M., Li, C., Ma, F., Ma, Y., Ma, Y."Interplay between lncRNAs and the PI3K/AKT signaling pathway in the progression of digestive system neoplasms (Review)". International Journal of Molecular Medicine 55, no. 1 (2025): 15. https://doi.org/10.3892/ijmm.2024.5456