Open Access

Impact of psychological stress on ovarian function: Insights, mechanisms and intervention strategies (Review)

  • Authors:
    • Yu Hu
    • Wuyang Wang
    • Wenqing Ma
    • Wenwen Wang
    • Wu Ren
    • Shixuan Wang
    • Fangfang Fu
    • Yan Li
  • View Affiliations

  • Published online on: December 18, 2024     https://doi.org/10.3892/ijmm.2024.5475
  • Article Number: 34
  • Copyright: © Hu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Mental stress may lead to ovarian dysfunction. Psychological stress disrupts ovarian function, leading to adverse in vitro fertilization outcomes, premature ovarian insufficiency and decreased ovarian reserve. Furthermore, psychological stress caused by decreased ovarian function and infertility can exacerbate the mental burden. In animals, psychological stress leads to ovarian insufficiency, resulting in irregular estrous cycles and decreased ovarian reserve. The present study summarizes effects of psychogenic stress on ovarian function and the underlying mechanisms, highlighting involvement of the hypothalamic‑pituitary‑adrenal, sympathetic‑adrenal‑medullary and hypothalamic‑pituitary‑ovarian axes, as well as the neuroendocrine‑metabolic network. Moreover, the present review outlines psychological intervention and metabolic strategies for improving ovarian function, offering potential new approaches for treating ovarian hypofunction. The present study aims to clarify understanding of psychological stress‑induced ovarian dysfunction and propose alternative intervention strategies for ovarian dysfunction and infertility.

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February-2025
Volume 55 Issue 2

Print ISSN: 1107-3756
Online ISSN:1791-244X

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Copy and paste a formatted citation
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Spandidos Publications style
Hu Y, Wang W, Ma W, Wang W, Ren W, Wang S, Fu F and Li Y: Impact of psychological stress on ovarian function: Insights, mechanisms and intervention strategies (Review). Int J Mol Med 55: 34, 2025.
APA
Hu, Y., Wang, W., Ma, W., Wang, W., Ren, W., Wang, S. ... Li, Y. (2025). Impact of psychological stress on ovarian function: Insights, mechanisms and intervention strategies (Review). International Journal of Molecular Medicine, 55, 34. https://doi.org/10.3892/ijmm.2024.5475
MLA
Hu, Y., Wang, W., Ma, W., Wang, W., Ren, W., Wang, S., Fu, F., Li, Y."Impact of psychological stress on ovarian function: Insights, mechanisms and intervention strategies (Review)". International Journal of Molecular Medicine 55.2 (2025): 34.
Chicago
Hu, Y., Wang, W., Ma, W., Wang, W., Ren, W., Wang, S., Fu, F., Li, Y."Impact of psychological stress on ovarian function: Insights, mechanisms and intervention strategies (Review)". International Journal of Molecular Medicine 55, no. 2 (2025): 34. https://doi.org/10.3892/ijmm.2024.5475