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Expression of heat shock protein 70 in leukocytes of patients with sepsis.

  • Authors:
    • G A Martins
    • C M David
    • C Mitchell
    • S L Rosas
    • M G da Costa Carvalho

  • View Affiliations

  • Published online on: April 1, 1999     https://doi.org/10.3892/ijmm.3.4.401
  • Pages: 401-405
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
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Abstract

The heat shock proteins are known to protect cells against diverse injuries such as cytotoxicity by TNFalpha acting mainly as chaperones for denatured proteins. Lipopolysaccharide stimulates the production and the release of numerous endogenous mediators of sepsis: tumor necrosis factor alpha, interleukin-1, and interleukin-6 that induce fever production. Moreover, temperature at 40 degrees C is sufficient to induce heat shock and attenuate both TNFalpha and IL-1 expression. We demonstrate a distinct profile in gene expression of HSP 70 family in leukocytes obtained from different phases of septic patients. Our findings strongly suggest that HSP 70 may play a role in the outcome of septic shock patients.

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Journal Cover

Apr 1999
Volume 3 Issue 4

Print ISSN: 1107-3756
Online ISSN:1791-244X

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  • Journal Metrics
  • Impact Factor: 5.7
  • Ranked Medicine Research and Experimental
    (total number of cites)
  • CiteScore: 12.3
  • CiteScore Rank: Q1: #28/347 Biochemistry, Genetics and Molecular Biology
  • Source Normalized Impact per Paper (SNIP): 1.022
  • SCImago Journal Rank (SJR): 1.167
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Spandidos Publications style
Martins G, David C, Mitchell C, Rosas S and da Costa Carvalho M: Expression of heat shock protein 70 in leukocytes of patients with sepsis.. Int J Mol Med 3: 401-405, 1999.
APA
Martins, G., David, C., Mitchell, C., Rosas, S., & da Costa Carvalho, M. (1999). Expression of heat shock protein 70 in leukocytes of patients with sepsis.. International Journal of Molecular Medicine, 3, 401-405. https://doi.org/10.3892/ijmm.3.4.401
MLA
Martins, G., David, C., Mitchell, C., Rosas, S., da Costa Carvalho, M."Expression of heat shock protein 70 in leukocytes of patients with sepsis.". International Journal of Molecular Medicine 3.4 (1999): 401-405.
Chicago
Martins, G., David, C., Mitchell, C., Rosas, S., da Costa Carvalho, M."Expression of heat shock protein 70 in leukocytes of patients with sepsis.". International Journal of Molecular Medicine 3, no. 4 (1999): 401-405. https://doi.org/10.3892/ijmm.3.4.401