Cell-dependent function of HIV-1 Vif for virus replication (Review).
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- Published online on: May 1, 1999 https://doi.org/10.3892/ijmm.3.5.473
- Pages: 473-479
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Abstract
It has been well established that the Vif protein of human immunodeficiency virus type 1 (HIV-1) acts late in the viral life cycle and increases the infectivity of the progeny virions in a producer cell-dependent manner. The virions produced in the absence of Vif in non-permissive cells (Delta Vif) are defective for a step(s) before and/or during reverse transcription. In this review, the functional and structural analyses of these virions including our new data are summarized.
