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Phytol induces programmed cell death in human lymphoid leukemia Molt 4B cells.

  • Authors:
    • T Komiya
    • M Kyohkon
    • S Ohwaki
    • J Eto
    • H Katsuzaki
    • K Imai
    • T Kataoka
    • K Yoshioka
    • Y Ishii
    • H Hibasami

  • View Affiliations

  • Published online on: October 1, 1999     https://doi.org/10.3892/ijmm.4.4.377
  • Pages: 377-457
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
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Abstract

The exposure of human lymphoid leukemia Molt 4B cells to phytol which was isolated from Lolium multiflorum Lam and identified by MS, and 1H- and 13C-NMR, led to both growth inhibition and the induction of programmed cell death (apoptosis). Morphological change showing apoptotic bodies was observed in the cells treated with phytol. The fragmentation by phytol of DNA to oligonucleosomal-sized fragments that are characteristics of apoptosis was observed to be concentration- and time-dependent. These findings suggest that growth inhibition by phytol of Molt 4B cells results from the induction of apoptosis in the cells.

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Journal Cover

Oct 1999
Volume 4 Issue 4

Print ISSN: 1107-3756
Online ISSN:1791-244X

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  • Journal Metrics
  • Impact Factor: 5.7
  • Ranked Medicine Research and Experimental
    (total number of cites)
  • CiteScore: 12.3
  • CiteScore Rank: Q1: #28/347 Biochemistry, Genetics and Molecular Biology
  • Source Normalized Impact per Paper (SNIP): 1.022
  • SCImago Journal Rank (SJR): 1.167
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Spandidos Publications style
Komiya T, Kyohkon M, Ohwaki S, Eto J, Katsuzaki H, Imai K, Kataoka T, Yoshioka K, Ishii Y, Hibasami H, Hibasami H, et al: Phytol induces programmed cell death in human lymphoid leukemia Molt 4B cells.. Int J Mol Med 4: 377-457, 1999.
APA
Komiya, T., Kyohkon, M., Ohwaki, S., Eto, J., Katsuzaki, H., Imai, K. ... Hibasami, H. (1999). Phytol induces programmed cell death in human lymphoid leukemia Molt 4B cells.. International Journal of Molecular Medicine, 4, 377-457. https://doi.org/10.3892/ijmm.4.4.377
MLA
Komiya, T., Kyohkon, M., Ohwaki, S., Eto, J., Katsuzaki, H., Imai, K., Kataoka, T., Yoshioka, K., Ishii, Y., Hibasami, H."Phytol induces programmed cell death in human lymphoid leukemia Molt 4B cells.". International Journal of Molecular Medicine 4.4 (1999): 377-457.
Chicago
Komiya, T., Kyohkon, M., Ohwaki, S., Eto, J., Katsuzaki, H., Imai, K., Kataoka, T., Yoshioka, K., Ishii, Y., Hibasami, H."Phytol induces programmed cell death in human lymphoid leukemia Molt 4B cells.". International Journal of Molecular Medicine 4, no. 4 (1999): 377-457. https://doi.org/10.3892/ijmm.4.4.377