Chrysobalanus icaco L. extract for antiangiogenic potential observation.

Alves De Paulo,S; Teruszkin Balassiano,I; Henriques Silva,N; Oliveira Castilho,R; Coelho Kaplan,M A; Currie Cabral,M; da Costa Carvalho,M G

doi:10.3892/ijmm.5.6.667

Chrysobalanus icaco L. extract for antiangiogenic potential observation.

Authors:
- S Alves De Paulo
- I Teruszkin Balassiano
- N Henriques Silva
- R Oliveira Castilho
- M A Coelho Kaplan
- M Currie Cabral
- M G da Costa Carvalho
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Affiliations: Instituto de Biofisica Carlos Chagas Filho, Laboratorio de Controle da Expressao Genica, Universidade Federal do Rio de Janeiro, Centro de Ciencias da Saude, Bloco C, Cidade Universitaria, CEP 21949-900, Rio de Janeiro, Brasil.
Published online on: June 1, 2000 https://doi.org/10.3892/ijmm.5.6.667
Pages: 667-676

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Abstract

Angiogenesis is an important process in several physiological situations and it is also implicated in the development of some diseases such as diabetes and cancer. This study investigated the antiangiogenic potential of Chrysobalanus icaco methanol extract in the chicken embrionary tissue. Clinical trials for cancer treatment using drugs based on this mechanism are already in progress. Chorioallantoic membrane model (CAM) of chicken embryos, with C. icaco methanol extract in plastic diskes was used. The results showed an average of 44% angiogenesis inhibition in CAM areas with the plant extract compared to the controls. The data indicate that C. icaco methanol extract reduce the formation of new blood vessels in chicken chorioallantoic membrane.