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Mutational analysis of HIV-1 gag proteins (review).

  • Authors:
    • M Miyaura
    • A Yoshida
    • A Sakurai
    • M Fujita
    • A H Koyama
    • A Adachi

  • View Affiliations

  • Published online on: September 1, 2000     https://doi.org/10.3892/ijmm.6.3.265
  • Pages: 265-274
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
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Abstract

The mature Gag proteins of human immunodeficiency virus type 1 (HIV-1) are major components of infectious virions, and thought to carry out numerous functions throughout the HIV-1 replication cycle. We have recently generated numerous gag gene mutants of HIV-1 to genetically study the functions of the Gag proteins. Through the biological and biochemical analyses, our HIV-1 gag mutants have been grouped into early (defective for uncoating/reverse transcription), late (defective for virion release/maturation), and early/late (defective for both steps) mutants. Many mutants are found to efficiently inhibit the replication of wild-type virus. Worthy of note, there are some early mutants which show host cell-dependent replication potential.

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Journal Cover

Sep 2000
Volume 6 Issue 3

Print ISSN: 1107-3756
Online ISSN:1791-244X

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  • Journal Metrics
  • Impact Factor: 5.7
  • Ranked Medicine Research and Experimental
    (total number of cites)
  • CiteScore: 12.3
  • CiteScore Rank: Q1: #28/347 Biochemistry, Genetics and Molecular Biology
  • Source Normalized Impact per Paper (SNIP): 1.022
  • SCImago Journal Rank (SJR): 1.167
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Spandidos Publications style
Miyaura M, Yoshida A, Sakurai A, Fujita M, Koyama A and Adachi A: Mutational analysis of HIV-1 gag proteins (review).. Int J Mol Med 6: 265-274, 2000.
APA
Miyaura, M., Yoshida, A., Sakurai, A., Fujita, M., Koyama, A., & Adachi, A. (2000). Mutational analysis of HIV-1 gag proteins (review).. International Journal of Molecular Medicine, 6, 265-274. https://doi.org/10.3892/ijmm.6.3.265
MLA
Miyaura, M., Yoshida, A., Sakurai, A., Fujita, M., Koyama, A., Adachi, A."Mutational analysis of HIV-1 gag proteins (review).". International Journal of Molecular Medicine 6.3 (2000): 265-274.
Chicago
Miyaura, M., Yoshida, A., Sakurai, A., Fujita, M., Koyama, A., Adachi, A."Mutational analysis of HIV-1 gag proteins (review).". International Journal of Molecular Medicine 6, no. 3 (2000): 265-274. https://doi.org/10.3892/ijmm.6.3.265