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International Journal of Molecular Medicine
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Print ISSN: 1107-3756 Online ISSN: 1791-244X
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Dec 2000 Volume 6 Issue 6

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Dec 2000 Volume 6 Issue 6

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Article

Multicolor spectral karyotype analysis of a transplantable human ileal carcinoid.

  • Authors:
    • H Sjögren
    • O Nilsson
    • M Behrendt
    • L Kölby
    • A M Jacobsen Levin
    • H Ahlman
    • G Stenman

  • View Affiliations / Copyright

    Affiliations: Department of Pathology, Lundberg Laboratory for Cancer Research, Goteborg University, Sahlgrenska University Hospital, Goteborg, Sweden.
  • Pages: 629-662
    |
    Published online on: December 1, 2000
       https://doi.org/10.3892/ijmm.6.6.629
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Abstract

In this report we present the results of a combined cytogenetic and multicolor spectral karyotype (SKY) analysis of a transplantable human ileal carcinoid (GOT1). By using SKY it was possible to identify the origin and organization of all clonal marker chromosomes and to identify cryptic translocations not detectable by conventional chromosome banding. The stemline karyotype of low passage GOT1 cells was interpreted as 43,XX, der(1)del(1)(?), inv(2)(p25q13), del(3)(p21), del(5)(q13q31), del(6)(q13), -9, -13, -15, del(16) (q22). Analysis of the GOT1 cells after about 2.5 years of propagation in nude mice allowed us to follow the in vivo progression of this tumor. Relatively few additional rearrangements had occurred during this period, indicating that the GOT1 cells are genetically stable. Most of the abnormalities detected result in loss of whole or parts of chromosomes, suggesting that loss of multiple chromosomal regions, presumably containing tumor suppressor genes, might be important genetic events in ileal carcinoids.

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Copy and paste a formatted citation
Spandidos Publications style
Sjögren H, Nilsson O, Behrendt M, Kölby L, Jacobsen Levin A, Ahlman H and Stenman G: Multicolor spectral karyotype analysis of a transplantable human ileal carcinoid.. Int J Mol Med 6: 629-662, 2000.
APA
Sjögren, H., Nilsson, O., Behrendt, M., Kölby, L., Jacobsen Levin, A., Ahlman, H., & Stenman, G. (2000). Multicolor spectral karyotype analysis of a transplantable human ileal carcinoid.. International Journal of Molecular Medicine, 6, 629-662. https://doi.org/10.3892/ijmm.6.6.629
MLA
Sjögren, H., Nilsson, O., Behrendt, M., Kölby, L., Jacobsen Levin, A., Ahlman, H., Stenman, G."Multicolor spectral karyotype analysis of a transplantable human ileal carcinoid.". International Journal of Molecular Medicine 6.6 (2000): 629-662.
Chicago
Sjögren, H., Nilsson, O., Behrendt, M., Kölby, L., Jacobsen Levin, A., Ahlman, H., Stenman, G."Multicolor spectral karyotype analysis of a transplantable human ileal carcinoid.". International Journal of Molecular Medicine 6, no. 6 (2000): 629-662. https://doi.org/10.3892/ijmm.6.6.629
Copy and paste a formatted citation
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Spandidos Publications style
Sjögren H, Nilsson O, Behrendt M, Kölby L, Jacobsen Levin A, Ahlman H and Stenman G: Multicolor spectral karyotype analysis of a transplantable human ileal carcinoid.. Int J Mol Med 6: 629-662, 2000.
APA
Sjögren, H., Nilsson, O., Behrendt, M., Kölby, L., Jacobsen Levin, A., Ahlman, H., & Stenman, G. (2000). Multicolor spectral karyotype analysis of a transplantable human ileal carcinoid.. International Journal of Molecular Medicine, 6, 629-662. https://doi.org/10.3892/ijmm.6.6.629
MLA
Sjögren, H., Nilsson, O., Behrendt, M., Kölby, L., Jacobsen Levin, A., Ahlman, H., Stenman, G."Multicolor spectral karyotype analysis of a transplantable human ileal carcinoid.". International Journal of Molecular Medicine 6.6 (2000): 629-662.
Chicago
Sjögren, H., Nilsson, O., Behrendt, M., Kölby, L., Jacobsen Levin, A., Ahlman, H., Stenman, G."Multicolor spectral karyotype analysis of a transplantable human ileal carcinoid.". International Journal of Molecular Medicine 6, no. 6 (2000): 629-662. https://doi.org/10.3892/ijmm.6.6.629
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