Expression of the α1D subunit of the L-type voltage gated calcium channel in human liver
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- Published online on: October 1, 2001 https://doi.org/10.3892/ijmm.8.4.413
- Pages: 413-416
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Abstract
Calcium channel blocker is useful for a variety of purposes and is effective for preventing hepatitis elicited by different inducers, suggesting its possible clinical application for treating hepatitis. The α1-subunit of the dihydropyridine-sensitive L-type calcium channel is a target of calcium channel blocker. For clinical application of calcium channel blocker, it is important to analyze the expression of the L-type calcium channel in the liver. However, the subtype of the L-type calcium channel α1-subunit expressed in the liver was not known. In the present study, the α1-subunit of the calcium channel expressed in human liver was systematically analyzed. The α1D subunit of the dihydropyridine-sensitive L-type voltage gated calcium channel is expressed relatively strongly in the liver and may play an important role in the liver.