Bis(maltolato)-oxovanadium (IV)-induced phosphorylation of PKB, GSK-3 and FOXO1 contributes toits glucoregulatory responses (Review)

  • Authors:
    • George Vardatsikos
    • Mohamad Z. Mehdi
    • Ashok K. Srivastava
  • View Affiliations

  • Published online on: September 1, 2009     https://doi.org/10.3892/ijmm_00000233
  • Pages: 303-309
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Abstract

Over the last several decades, a large body of evidence has accumulated to suggest that organo-vanadium compounds (OVC) are more potent than inorganic vanadium salts in regulating hyperglycemia and insulin-resistance in rodent models of both type I and type II diabetes. Among these OVC, vanadium (IV) oxo bis(maltolato) (BMOV) was the first to be investigated for its higher potency over inorganic vanadium salts in eliciting insulin-like properties in both in vitro and in vivo systems. While the precise molecular mechanism by which BMOV exerts its insulin-mimetic effects remains poorly defined, studies have shown that BMOV is a potent activator of several key components of the insulin signaling pathways, such as phosphatidyl-inositol 3-kinase (PI3-K), and its downstream effector, protein kinase B (PKB). In addition, BMOV-induced phosphorylation of PKB has also been associated with the enhanced phosphorylation of glycogen synthase kinase-3 (GSK-3) and forkhead box protein 1 (FOXO1). Since PKB is instrumental in mediating the effects of insulin on glucose transport, glycogen synthesis and gluconeogenesis, it is reasonable to suggest that activation of this pathway by BMOV serves as a mechanism for its insulin-like effects.

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September 2009
Volume 24 Issue 3

Print ISSN: 1107-3756
Online ISSN:1791-244X

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Spandidos Publications style
Vardatsikos G, Mehdi MZ and Srivastava AK: Bis(maltolato)-oxovanadium (IV)-induced phosphorylation of PKB, GSK-3 and FOXO1 contributes toits glucoregulatory responses (Review). Int J Mol Med 24: 303-309, 2009.
APA
Vardatsikos, G., Mehdi, M.Z., & Srivastava, A.K. (2009). Bis(maltolato)-oxovanadium (IV)-induced phosphorylation of PKB, GSK-3 and FOXO1 contributes toits glucoregulatory responses (Review). International Journal of Molecular Medicine, 24, 303-309. https://doi.org/10.3892/ijmm_00000233
MLA
Vardatsikos, G., Mehdi, M. Z., Srivastava, A. K."Bis(maltolato)-oxovanadium (IV)-induced phosphorylation of PKB, GSK-3 and FOXO1 contributes toits glucoregulatory responses (Review)". International Journal of Molecular Medicine 24.3 (2009): 303-309.
Chicago
Vardatsikos, G., Mehdi, M. Z., Srivastava, A. K."Bis(maltolato)-oxovanadium (IV)-induced phosphorylation of PKB, GSK-3 and FOXO1 contributes toits glucoregulatory responses (Review)". International Journal of Molecular Medicine 24, no. 3 (2009): 303-309. https://doi.org/10.3892/ijmm_00000233