KINASE GROUP PROTOONCOGENES IN NON-HODGKINS-LYMPHOMAS AND NONMALIGNANT LYMPHOID-TISSUES - ANALYSIS OF THEIR EXPRESSION BY INSITU HYBRIDIZATION ASSAYS
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- Published online on: August 1, 1992 https://doi.org/10.3892/ijo.1.3.257
- Pages: 257-264
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Abstract
Expression of src related proto-oncogenes in non-Hodgkin's lymphomas and non-malignant lymph nodes was analyzed by means of in situ hybridization assays with biotinylated DNA probes. In 36 cases of non-Hodgkin's lymphomas, both c-mos and c-abl were expressed in 27 cases, and c-erbB and c-src were expressed in 15 cases and 7 cases, respectively. No case expressed c-fps or c-yes. On the contrary, in 11 cases of non-malignant lymph nodes c-erbB and c-mos was expressed in only 3 cases. No other proto-oncogenes were expressed. Lymphomas in general express multiple proto-oncogenes simultaneously. A variety of combinations of expressed proto-oncogenes were observed suggesting diversity among non-Hodgkin's lymphomas in biological characteristics. However, a clear association with the expression of a single proto-oncogene or the number of expressed proto-oncogenes with T cell / B cell types, or the histopathological classification of NHL, or disease prognosis was not observed.
