THE TREATMENT OF COLORECTAL HEPATIC METASTASES BY CONTINUOUS LOCAL INFUSION OF INTERLEUKIN-2
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- Published online on: October 1, 1992 https://doi.org/10.3892/ijo.1.5.607
- Pages: 607-610
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Abstract
Patients with hepatic metastases from colorectal cancer appear to be resistant to most forms of therapy. Recent reports suggest synergism between systemically administered recombinant interleukin-2 (rIL-2) and 5-fluorouracil (5-FU) with responses documented in the treatment of advanced colonic tumours albeit with significant toxicity. Local continuous infusion of rIL-2 into selected sites may reduce toxicity and increase efficacy. We have assessed the feasibility of continuously infusing rIL-2 into the region of a hepatic metastasis in 3 patients via a catheter placed within the liver under ultrasound guidance in a regimen including systemic rIL-2 and 5FU.