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Human papillomavirus type-16 (HPV-16) major transforming proteins functionally interact with interferon signaling mechanisms

  • Authors:
    • S Perea
    • O López-Ocejo
    • A von Gabain
    • M De J Araña

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  • Published online on: July 1, 1997     https://doi.org/10.3892/ijo.11.1.169
  • Pages: 169-173
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Abstract

Since the IFN system has been implicated in cell growth and differentiation control mechanisms, we evaluated the influence of the expression of HPV-16 E6 and E7 oncoproteins on IFN signaling by using cotransfection experiments. Both viral oncoproteins differentially interfered with the inducibility of IFN-beta promoter by Sendai virus. The activation by IFN-gamma of a GBP ISRE reporter was dramatically affected by both viral proteins suggesting a disruption of STATs/IRFs function. Further, the inducibility of 6-16 gene ISRE reporter by IFN-alpha was decreased to varying degrees by both viral oncoproteins, implying that ISGF3 function is also impaired. Taken together, these observations suggest that HPV-16 negatively interacts with cellular targets of the IFN system, and these interactions may be implicated in cellular transformation caused by HPVs and their refractory response to IFN treatment.

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Journal Cover

July 1997
Volume 11 Issue 1

Print ISSN: 1019-6439
Online ISSN:1791-2423

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  • Journal Metrics
  • Impact Factor: 4.5
  • Ranked Oncology
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  • CiteScore: 9.6
  • CiteScore Rank: Q1: #66/404 Oncology
  • Source Normalized Impact per Paper (SNIP): 0.88
  • SCImago Journal Rank (SJR): 1.099
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Spandidos Publications style
Perea S, López-Ocejo O, von Gabain A and De J Araña M: Human papillomavirus type-16 (HPV-16) major transforming proteins functionally interact with interferon signaling mechanisms. Int J Oncol 11: 169-173, 1997.
APA
Perea, S., López-Ocejo, O., von Gabain, A., & De J Araña, M. (1997). Human papillomavirus type-16 (HPV-16) major transforming proteins functionally interact with interferon signaling mechanisms. International Journal of Oncology, 11, 169-173. https://doi.org/10.3892/ijo.11.1.169
MLA
Perea, S., López-Ocejo, O., von Gabain, A., De J Araña, M."Human papillomavirus type-16 (HPV-16) major transforming proteins functionally interact with interferon signaling mechanisms". International Journal of Oncology 11.1 (1997): 169-173.
Chicago
Perea, S., López-Ocejo, O., von Gabain, A., De J Araña, M."Human papillomavirus type-16 (HPV-16) major transforming proteins functionally interact with interferon signaling mechanisms". International Journal of Oncology 11, no. 1 (1997): 169-173. https://doi.org/10.3892/ijo.11.1.169