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p53 is involved in the inhibition of cell proliferation mediated by activin A in cultured human prostate cancer LNCaP cells

  • Authors:
    • S Ying
    • Z Zhang
    • Y Batres
    • Y Zhao
    • S Lin
    • G Li

  • View Affiliations

  • Published online on: September 1, 1997     https://doi.org/10.3892/ijo.11.3.591
  • Pages: 591-595
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
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Abstract

Activin A in a concentration ranging from 0.7 to 75 ng/ml specifically inhibited cell growth of an androgen-sensitive human prostate cancer line, LNCaP, but had no effects on two androgen-insensitive human prostate cancer lines, PC3 and DU-145. This activin-mediated inhibition of cell growth in LNCaP cells results from a decrease of cell proliferation and an increase of apoptosis. Northern blot analysis of mRNA expression encoding human p53 in untreated and activin-treated LNCaP cells resulted in upregulation of p53 gene expression. We conclude that autocrine inhibition of cell growth in LNCaP cells by activin is in part related to the expression of the p53 gene.

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Journal Cover

September 1997
Volume 11 Issue 3

Print ISSN: 1019-6439
Online ISSN:1791-2423

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  • Journal Metrics
  • Impact Factor: 4.5
  • Ranked Oncology
    (total number of cites)
  • CiteScore: 9.6
  • CiteScore Rank: Q1: #66/404 Oncology
  • Source Normalized Impact per Paper (SNIP): 0.88
  • SCImago Journal Rank (SJR): 1.099
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Spandidos Publications style
Ying S, Zhang Z, Batres Y, Zhao Y, Lin S and Li G: p53 is involved in the inhibition of cell proliferation mediated by activin A in cultured human prostate cancer LNCaP cells. Int J Oncol 11: 591-595, 1997.
APA
Ying, S., Zhang, Z., Batres, Y., Zhao, Y., Lin, S., & Li, G. (1997). p53 is involved in the inhibition of cell proliferation mediated by activin A in cultured human prostate cancer LNCaP cells. International Journal of Oncology, 11, 591-595. https://doi.org/10.3892/ijo.11.3.591
MLA
Ying, S., Zhang, Z., Batres, Y., Zhao, Y., Lin, S., Li, G."p53 is involved in the inhibition of cell proliferation mediated by activin A in cultured human prostate cancer LNCaP cells". International Journal of Oncology 11.3 (1997): 591-595.
Chicago
Ying, S., Zhang, Z., Batres, Y., Zhao, Y., Lin, S., Li, G."p53 is involved in the inhibition of cell proliferation mediated by activin A in cultured human prostate cancer LNCaP cells". International Journal of Oncology 11, no. 3 (1997): 591-595. https://doi.org/10.3892/ijo.11.3.591