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Inhibitory effect of a serine protease inhibitor, FOY-305 on the invasion and metastasis of human pancreatic cancers

  • Authors:
    • T Ohta
    • F Futagami
    • H Tajima
    • H Kitagawa
    • M Kayahara
    • T Nagakawa
    • K Miwa
    • M Yamamoto
    • S Iseki
    • Y Nakanuma
    • T Terada

  • View Affiliations

  • Published online on: October 1, 1997     https://doi.org/10.3892/ijo.11.4.813
  • Pages: 813-817
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Abstract

We examined the inhibitory effect of a serine protease inhibitor, FOY-305, on the invasion and metastasis of human pancreatic cancers. The in vitro matrigel invasion assay showed that the invasiveness of Capan-1 human pancreatic cancer cells was inhibited by FOY-305 treatment in a dose-dependent manner at concentrations greater than 100 nM. Intrasplenic injection of Capan-1 cells in nude mice resulted in frequent metastases to liver, however, its incidence was significantly decreased by FOY-305 treatment. These findings suggest that a serine protease inhibitor, FOY-305 can inhibit tumor invasion and metastasis by blocking the serine protease-mediated activation cascade.

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Journal Cover

October 1997
Volume 11 Issue 4

Print ISSN: 1019-6439
Online ISSN:1791-2423

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  • Journal Metrics
  • Impact Factor: 4.5
  • Ranked Oncology
    (total number of cites)
  • CiteScore: 9.6
  • CiteScore Rank: Q1: #66/404 Oncology
  • Source Normalized Impact per Paper (SNIP): 0.88
  • SCImago Journal Rank (SJR): 1.099
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Spandidos Publications style
Ohta T, Futagami F, Tajima H, Kitagawa H, Kayahara M, Nagakawa T, Miwa K, Yamamoto M, Iseki S, Nakanuma Y, Nakanuma Y, et al: Inhibitory effect of a serine protease inhibitor, FOY-305 on the invasion and metastasis of human pancreatic cancers. Int J Oncol 11: 813-817, 1997.
APA
Ohta, T., Futagami, F., Tajima, H., Kitagawa, H., Kayahara, M., Nagakawa, T. ... Terada, T. (1997). Inhibitory effect of a serine protease inhibitor, FOY-305 on the invasion and metastasis of human pancreatic cancers. International Journal of Oncology, 11, 813-817. https://doi.org/10.3892/ijo.11.4.813
MLA
Ohta, T., Futagami, F., Tajima, H., Kitagawa, H., Kayahara, M., Nagakawa, T., Miwa, K., Yamamoto, M., Iseki, S., Nakanuma, Y., Terada, T."Inhibitory effect of a serine protease inhibitor, FOY-305 on the invasion and metastasis of human pancreatic cancers". International Journal of Oncology 11.4 (1997): 813-817.
Chicago
Ohta, T., Futagami, F., Tajima, H., Kitagawa, H., Kayahara, M., Nagakawa, T., Miwa, K., Yamamoto, M., Iseki, S., Nakanuma, Y., Terada, T."Inhibitory effect of a serine protease inhibitor, FOY-305 on the invasion and metastasis of human pancreatic cancers". International Journal of Oncology 11, no. 4 (1997): 813-817. https://doi.org/10.3892/ijo.11.4.813