Fibroblast growth factor-2 and -9 regulate proliferation and production of matrix metalloproteinases in human gliomas.

Miyagi,N; Kato,S; Terasaki,M; Shigemori,M; Morimatsu,M

doi:10.3892/ijo.12.5.1085

Fibroblast growth factor-2 and -9 regulate proliferation and production of matrix metalloproteinases in human gliomas.

Authors:
- N Miyagi
- S Kato
- M Terasaki
- M Shigemori
- M Morimatsu
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Affiliations: Department of Pathology, Kurume University, School of Medicine, Japan.
Published online on: May 1, 1998 https://doi.org/10.3892/ijo.12.5.1085
Pages: 1085-1175

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Abstract

Fibroblast growth factor (FGF) signaling has been recognized in human gliomas. We tested the effect of FGF-2 and FGF-9 on the proliferation and the expression of matrix metalloproteinases (MMPs) and their inhibitor (TIMP-1) in vitro. Both FGFs showed mitogenic activity on U251MG and NMC-G1 cells. MMP-1 expression and collagenolytic activity of NMC-G1 but not of U251MG, and TIMP-1 expression of both cells were stimulated by FGFs. MMP-2 expression, gelatinolytic activity, and chemoinvasion on the matrigel were not altered. FGFs may regulate proliferation and microenvironmental factors independently in each glioma type.