Effects of granisetron in children undergoing high-dose chemotherapy: a multi-institutional, cross-over study.

Tsuchida,Y; Hayashi,Y; Asami,K; Yamamoto,K; Yokoyama,J; Mugishima,H; Honna,T; Mimaya,J; Hara,F; Sawada,T; Matsumura,T; Suita,S; Sugimoto,T; Kaneko,M

doi:10.3892/ijo.14.4.673

Effects of granisetron in children undergoing high-dose chemotherapy: a multi-institutional, cross-over study.

Authors:
- Y Tsuchida
- Y Hayashi
- K Asami
- K Yamamoto
- J Yokoyama
- H Mugishima
- T Honna
- J Mimaya
- F Hara
- T Sawada
- T Matsumura
- S Suita
- T Sugimoto
- M Kaneko
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Affiliations: Gunma Children's Medical Center, Hokkitsu, Seta-gun, Gunma 377-8577, Japan.
Published online on: April 1, 1999 https://doi.org/10.3892/ijo.14.4.673
Pages: 673-682

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Abstract

The efficacy of granisetron hydrochloride 20 microg/kg and 40 microg/kg were compared using a cross-over method to determine the optimal dose in children with solid tumors receiving high-dose chemotherapy. Granisetron controlled the onset of vomiting in 17 of 23 patients (73.9%) who were given 40 microg/kg of granisetron, while 8 of 21 patients (38.1%) were free of vomiting in the 20 microg/kg group. The average frequency of vomiting was 7.22 times in the 20 microg/kg dose versus 4.44 times in the 40 microg/kg dose. No safety problems were associated with either dose. The 40 microg/kg dose of granisetron appears to be more optimal.