Acyclic nucleotide analogues suppress growth and induce apoptosis in human leukemia cell lines.
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- Published online on: April 1, 1999 https://doi.org/10.3892/ijo.14.4.745
- Pages: 745-797
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Abstract
Acyclic nucleotide analogues perturb DNA replication by terminating the growing DNA chain. The analogues selected for testing on human leukemia cell lines, namely 9-[2-(phosphonomethoxy)ethyl]adenine (PMEA), 9-[2-(phosphonomethoxy)ethyl]-2,6-diaminopurine (PMEDAP), and 9-[2-(phosphonomethoxy)ethyl]guanine (PMEG) exhibited growth-inhibiting activity at low concentrations, and apoptosis-inducing activity at high concentrations. A common feature was a reduction of the proportion of G1 cell cycle phase. Activities of the analogues increased in the order PMEA
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Apr 1999
Volume 14 Issue 4
Print ISSN: 1019-6439
Online ISSN:1791-2423