Prognostic markers in clinically localised prostate cancer.

Bai,X Z; Masters,J R; O'Donoghue,N; Kirby,R; Pan,L X; Young,M; Stafford,M; Parkinson,M C

doi:10.3892/ijo.14.4.785

Prognostic markers in clinically localised prostate cancer.

Authors:
- X Z Bai
- J R Masters
- N O'Donoghue
- R Kirby
- L X Pan
- M Young
- M Stafford
- M C Parkinson
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Affiliations: Department of Urology, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi 530027, China.
Published online on: April 1, 1999 https://doi.org/10.3892/ijo.14.4.785
Pages: 785-876

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Abstract

The prognostic value of immunohistochemical staining of P53, BCL-2, p27kip1, PSA, AR and MIB-1 was compared with that of established prognostic variables (Gleason score, surgical margins, tumour volume) following radical prostatectomy. Five groups were selected: negative margins with stable serum PSA (n=11), negative margins with rising serum PSA (n=7), positive margins with stable serum PSA (n=7), positive margins with rising serum PSA (6) and patients with micrometastatic disease diagnosed in lymph nodes removed during radical prostatectomy (n=8). Gleason score and tumour volume were of prognostic significance and immunohistochemical staining for MIB-1 and BCL-2 showed added independent prognostic significance in multivariate analysis.