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Analysis of Bcl-2, Bax and Survivin genes in uterine cancer.

  • Authors:
    • Y Saitoh
    • Y Yaginuma
    • M Ishikawa

  • View Affiliations

  • Published online on: July 1, 1999     https://doi.org/10.3892/ijo.15.1.137
  • Pages: 137-178
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Abstract

To investigate the role of the apoptosis-related genes, Bcl-2, Bax and Survivin genes were analyzed. For the Bax gene, abnormality was detected in 1 of 7 cervical and 1 of 6 endometrial cancer cell lines, 1 of 25 cervical cancer tissues and none of 17 endometrial cancer tissues using PCR-SSCP. In 4 cervical and 2 endometrial cancer cell lines, the ratio of Bcl-2 to Bax expression was higher than the control ratio using Western blotting. Survivin mRNA was detectable in all cell lines and all cancer tissues. The data suggested that these apoptosis-related genes may play important roles in the pathway of carcinogenesis of human uterine cancer.

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Journal Cover

Jul 1999
Volume 15 Issue 1

Print ISSN: 1019-6439
Online ISSN:1791-2423

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  • Journal Metrics
  • Impact Factor: 4.5
  • Ranked Oncology
    (total number of cites)
  • CiteScore: 9.6
  • CiteScore Rank: Q1: #66/404 Oncology
  • Source Normalized Impact per Paper (SNIP): 0.88
  • SCImago Journal Rank (SJR): 1.099
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Spandidos Publications style
Saitoh Y, Yaginuma Y and Ishikawa M: Analysis of Bcl-2, Bax and Survivin genes in uterine cancer.. Int J Oncol 15: 137-178, 1999.
APA
Saitoh, Y., Yaginuma, Y., & Ishikawa, M. (1999). Analysis of Bcl-2, Bax and Survivin genes in uterine cancer.. International Journal of Oncology, 15, 137-178. https://doi.org/10.3892/ijo.15.1.137
MLA
Saitoh, Y., Yaginuma, Y., Ishikawa, M."Analysis of Bcl-2, Bax and Survivin genes in uterine cancer.". International Journal of Oncology 15.1 (1999): 137-178.
Chicago
Saitoh, Y., Yaginuma, Y., Ishikawa, M."Analysis of Bcl-2, Bax and Survivin genes in uterine cancer.". International Journal of Oncology 15, no. 1 (1999): 137-178. https://doi.org/10.3892/ijo.15.1.137