MAGE-specific cytotoxic T lymphocytes require non-specific CD54 adherence receptors on carcinoma cells.

  • Authors:
    • K Tahara
    • N Sadanaga
    • H Nagashima
    • S Kitano
    • M Mori
  • View Affiliations

  • Published online on: October 1, 2000     https://doi.org/10.3892/ijo.17.4.805
  • Pages: 805-815
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Abstract

We investigated several factors that could regulate the susceptibility of carcinoma cells to MAGE-2-specific CTL mediated lysis. Cytofluorometric analysis showed that the cytolysis correlated with the expression of CD54. IFN-gamma treatment induced the TAP-1 and LMP-2 genes, continuously up-regulated the HLA class I expression and increased cytolysis. Although HLA class I were highly induced in MRKnu1 cells, CD54 was not induced and the cytolysis was minimal. Cytotolysis of IFN-gamma-treated MKN-1 cells was completely inhibited by a monoclonal anti-CD54 antibody. These results suggest that HLA-restricted CTL lysis requires non-specific CD54 adherence receptors in addition to specific TCR signals.

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Oct 2000
Volume 17 Issue 4

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Spandidos Publications style
Tahara K, Sadanaga N, Nagashima H, Kitano S and Mori M: MAGE-specific cytotoxic T lymphocytes require non-specific CD54 adherence receptors on carcinoma cells.. Int J Oncol 17: 805-815, 2000.
APA
Tahara, K., Sadanaga, N., Nagashima, H., Kitano, S., & Mori, M. (2000). MAGE-specific cytotoxic T lymphocytes require non-specific CD54 adherence receptors on carcinoma cells.. International Journal of Oncology, 17, 805-815. https://doi.org/10.3892/ijo.17.4.805
MLA
Tahara, K., Sadanaga, N., Nagashima, H., Kitano, S., Mori, M."MAGE-specific cytotoxic T lymphocytes require non-specific CD54 adherence receptors on carcinoma cells.". International Journal of Oncology 17.4 (2000): 805-815.
Chicago
Tahara, K., Sadanaga, N., Nagashima, H., Kitano, S., Mori, M."MAGE-specific cytotoxic T lymphocytes require non-specific CD54 adherence receptors on carcinoma cells.". International Journal of Oncology 17, no. 4 (2000): 805-815. https://doi.org/10.3892/ijo.17.4.805