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Brca1 and Brca2 protein expression patterns in different tissues of murine origin

  • Authors:
    • Dominique J. Bernard-Gallon
    • Monique Peffault De Latour
    • Valerie Sylvain
    • Cecile Vissac
    • Benedicte Aunoble
    • Jacques Chassagne
    • Yves-Jean Bignon

  • View Affiliations

  • Published online on: February 1, 2001     https://doi.org/10.3892/ijo.18.2.271
  • Pages: 271-280
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Abstract

We have analyzed by immunohistochemistry Brca1 and Brca2 protein expression in mouse during embryonic development, in adult tissues, and during postnatal mammary gland development. Our observations confirm previous localization of Brca1 and Brca2 mRNA on frozen sections by in situ hybridization, and demonstrate that Brca1 and Brca2 proteins are expressed in rapidly proliferating cell types undergoing differentiation. These results imply that Brca1 and Brca2 proteins are involved in the process of proliferation and differentiation in multiple tissues, notably in the mammary gland during pregnancy and lactation.

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February 2001
Volume 18 Issue 2

Print ISSN: 1019-6439
Online ISSN:1791-2423

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  • Journal Metrics
  • Impact Factor: 4.5
  • Ranked Oncology
    (total number of cites)
  • CiteScore: 9.6
  • CiteScore Rank: Q1: #66/404 Oncology
  • Source Normalized Impact per Paper (SNIP): 0.88
  • SCImago Journal Rank (SJR): 1.099
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Spandidos Publications style
Bernard-Gallon DJ, De Latour MP, Sylvain V, Vissac C, Aunoble B, Chassagne J and Bignon Y: Brca1 and Brca2 protein expression patterns in different tissues of murine origin. Int J Oncol 18: 271-280, 2001.
APA
Bernard-Gallon, D.J., De Latour, M.P., Sylvain, V., Vissac, C., Aunoble, B., Chassagne, J., & Bignon, Y. (2001). Brca1 and Brca2 protein expression patterns in different tissues of murine origin. International Journal of Oncology, 18, 271-280. https://doi.org/10.3892/ijo.18.2.271
MLA
Bernard-Gallon, D. J., De Latour, M. P., Sylvain, V., Vissac, C., Aunoble, B., Chassagne, J., Bignon, Y."Brca1 and Brca2 protein expression patterns in different tissues of murine origin". International Journal of Oncology 18.2 (2001): 271-280.
Chicago
Bernard-Gallon, D. J., De Latour, M. P., Sylvain, V., Vissac, C., Aunoble, B., Chassagne, J., Bignon, Y."Brca1 and Brca2 protein expression patterns in different tissues of murine origin". International Journal of Oncology 18, no. 2 (2001): 271-280. https://doi.org/10.3892/ijo.18.2.271