Eicosapentaenoic acid modulates cyclin expression and arrests cell cycle progression in human leukemic K-562 cells
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- Published online on: October 1, 2001 https://doi.org/10.3892/ijo.19.4.845
- Pages: 845-849
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Abstract
Eicosapentaenoic acid (EPA) is a polyunsaturated fatty acid (20:5ω3) found primarily in aquatic organisms. We have shown previously that EPA inhibits the growth but is not toxic to human leukemic K-562 cells. In this study, the anti-proliferative effect of EPA on the leukemic cells was further determined and its impacts on cell cycle progression and cyclin expression were investigated. EPA inhibited proliferation of K-562 cells, which was associated with accumulation of G0/G1 cells and down-regulation of cyclin E expression. Cyclin B1-expressing cells were also reduced showing that down-regulation of cyclin expression might be important in the anti-proliferation of EPA.
