REGULATION OF BASOPHILIC AND ERYTHROID-DIFFERENTIATION OF A HUMAN CHRONIC MYELOGENOUS LEUKEMIA-CELL LINE, KU812F, BY INTERLEUKIN-3 AND STEM-CELL FACTOR
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- Published online on: February 1, 1993 https://doi.org/10.3892/ijo.2.2.213
- Pages: 213-219
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Abstract
We have investigated the effects of c-kit ligand (stem cell factor [SCF]) and interleukin-3 (IL-3) on proliferation and differentiation of a human chronic myelogenous leukemia cell line, KU812F, which can differentiate toward erythroid and basophilic lineages. When purified c-kit-positive cells (approximately 20% of KU812F cells) were used as a target, SCF induced not only proliferation but also augumented erythroid differentiation of the cells, while IL-3 did promote basophilic differentiation. Further, analyses of in situ hybridization and cell sorting with anti-c-kit antibody showed that the expression of c-kit decreased along with differentiation from immature to mature basophils and erythroid cells.