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MODIFIED BETA-TURNS IN BREAST CARCINOMA-ASSOCIATED MUC1 RELATED PEPTIDES

  • Authors:
    • MJ SCANLON
    • MR PRICE
    • SJB TENDLER

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  • Published online on: February 1, 1993     https://doi.org/10.3892/ijo.2.2.271
  • Pages: 271-273
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Abstract

The solution structure of two carcinoma-associated MUC1 core related peptides has been investigated by nuclear magnetic resonance (n.m.r.) spectroscopy. The peptide APDTRPAPG resembles previously studied MUC1 related peptides with a type I beta-turn identified in the region PDTR. This portion of the peptide has previously been identified as the binding site for the monoclonal antibodies HMFG-1 and HMFG-2. The peptide where the D has been replaced by its homologue E, which is selectively recognized by the antibody HMFG-1 but not HMFG-2, appears to have a modified tum region. While amide to amide through space connections are observed the results suggest a more open tum structure.

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February 1993
Volume 2 Issue 2

Print ISSN: 1019-6439
Online ISSN:1791-2423

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  • Impact Factor: 4.5
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  • CiteScore: 9.6
  • CiteScore Rank: Q1: #66/404 Oncology
  • Source Normalized Impact per Paper (SNIP): 0.88
  • SCImago Journal Rank (SJR): 1.099
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Spandidos Publications style
SCANLON M, PRICE M and TENDLER S: MODIFIED BETA-TURNS IN BREAST CARCINOMA-ASSOCIATED MUC1 RELATED PEPTIDES. Int J Oncol 2: 271-273, 1993.
APA
SCANLON, M., PRICE, M., & TENDLER, S. (1993). MODIFIED BETA-TURNS IN BREAST CARCINOMA-ASSOCIATED MUC1 RELATED PEPTIDES. International Journal of Oncology, 2, 271-273. https://doi.org/10.3892/ijo.2.2.271
MLA
SCANLON, M., PRICE, M., TENDLER, S."MODIFIED BETA-TURNS IN BREAST CARCINOMA-ASSOCIATED MUC1 RELATED PEPTIDES". International Journal of Oncology 2.2 (1993): 271-273.
Chicago
SCANLON, M., PRICE, M., TENDLER, S."MODIFIED BETA-TURNS IN BREAST CARCINOMA-ASSOCIATED MUC1 RELATED PEPTIDES". International Journal of Oncology 2, no. 2 (1993): 271-273. https://doi.org/10.3892/ijo.2.2.271