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CHARACTERIZATION OF SPONTANEOUS IMMUNOLOGICAL REGRESSION IN HISTIOCYTOMA .2. PARTICIPATION OF TUMOR-NECROSIS-FACTOR

  • Authors:
    • A KHAR
    • AL KUMARI
    • AM ALI

  • View Affiliations

  • Published online on: March 1, 1993     https://doi.org/10.3892/ijo.2.3.399
  • Pages: 399-402
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
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Abstract

Animals which reject a histiocytoma show extensive necrosis of the tumor and produce TNF in an autologus manner without any external stimulation. An excellent correlation between the expression of TNF and the levels of TNF in circulation during tumor regression is demonstrated. TNF purified from the sera of tumor regressing animals is cytotoxic to AK-5 cells in vitro. Anti TNF antibody neutralizes the cytotoxic activity of TNF against AK-5 cells in vitro. Injection of monoclonal antibodies against TNF into tumor bearing animals delays the appearance of necrosis in AK-5 tumors thereby suggesting a direct role for TNF in AK-5 rejection.

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March 1993
Volume 2 Issue 3

Print ISSN: 1019-6439
Online ISSN:1791-2423

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  • Journal Metrics
  • Impact Factor: 4.5
  • Ranked Oncology
    (total number of cites)
  • CiteScore: 9.6
  • CiteScore Rank: Q1: #66/404 Oncology
  • Source Normalized Impact per Paper (SNIP): 0.88
  • SCImago Journal Rank (SJR): 1.099
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Spandidos Publications style
KHAR A, KUMARI A and ALI A: CHARACTERIZATION OF SPONTANEOUS IMMUNOLOGICAL REGRESSION IN HISTIOCYTOMA .2. PARTICIPATION OF TUMOR-NECROSIS-FACTOR. Int J Oncol 2: 399-402, 1993.
APA
KHAR, A., KUMARI, A., & ALI, A. (1993). CHARACTERIZATION OF SPONTANEOUS IMMUNOLOGICAL REGRESSION IN HISTIOCYTOMA .2. PARTICIPATION OF TUMOR-NECROSIS-FACTOR. International Journal of Oncology, 2, 399-402. https://doi.org/10.3892/ijo.2.3.399
MLA
KHAR, A., KUMARI, A., ALI, A."CHARACTERIZATION OF SPONTANEOUS IMMUNOLOGICAL REGRESSION IN HISTIOCYTOMA .2. PARTICIPATION OF TUMOR-NECROSIS-FACTOR". International Journal of Oncology 2.3 (1993): 399-402.
Chicago
KHAR, A., KUMARI, A., ALI, A."CHARACTERIZATION OF SPONTANEOUS IMMUNOLOGICAL REGRESSION IN HISTIOCYTOMA .2. PARTICIPATION OF TUMOR-NECROSIS-FACTOR". International Journal of Oncology 2, no. 3 (1993): 399-402. https://doi.org/10.3892/ijo.2.3.399