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THE ANTIANDROGEN FLUTAMIDE INHIBITS GROWTH OF MCF-7 HUMAN BREAST-CANCER CELL-LINE

  • Authors:
    • M DIMONACO
    • E BRIGNARDELLO
    • L LEONARDI
    • V GATTO
    • M GALLO
    • A PIZZINI
    • G BOCCUZZI

  • View Affiliations

  • Published online on: April 1, 1993     https://doi.org/10.3892/ijo.2.4.653
  • Pages: 653-656
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
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Abstract

The antiandrogen flutamide (FLU) has been reported to exert antiproliferative action on both male and postmenopausal breast cancer and to inhibit growth of chemically induced rat breast cancer. We studied the effects of various concentrations of FLU on the growth of the ER+, AR+ and PR+ MCF-7 and the ER-, AR- and PR- MDA-MB-231 human breast cancer cell lines. The growth of MCF-7 cells in both steroid free and estradiol supplemented media was inhibited by FLU. MDA-MB-231 cell growth was not affected by FLU. Our data show a direct inhibitory action of FLU on human breast cancer cells and suggest a different susceptibility to the antiproliferative action of FLU, which seems to be related to the steroid receptor status.

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April 1993
Volume 2 Issue 4

Print ISSN: 1019-6439
Online ISSN:1791-2423

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  • Journal Metrics
  • Impact Factor: 4.5
  • Ranked Oncology
    (total number of cites)
  • CiteScore: 9.6
  • CiteScore Rank: Q1: #66/404 Oncology
  • Source Normalized Impact per Paper (SNIP): 0.88
  • SCImago Journal Rank (SJR): 1.099
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Spandidos Publications style
DIMONACO M, BRIGNARDELLO E, LEONARDI L, GATTO V, GALLO M, PIZZINI A and BOCCUZZI G: THE ANTIANDROGEN FLUTAMIDE INHIBITS GROWTH OF MCF-7 HUMAN BREAST-CANCER CELL-LINE. Int J Oncol 2: 653-656, 1993.
APA
DIMONACO, M., BRIGNARDELLO, E., LEONARDI, L., GATTO, V., GALLO, M., PIZZINI, A., & BOCCUZZI, G. (1993). THE ANTIANDROGEN FLUTAMIDE INHIBITS GROWTH OF MCF-7 HUMAN BREAST-CANCER CELL-LINE. International Journal of Oncology, 2, 653-656. https://doi.org/10.3892/ijo.2.4.653
MLA
DIMONACO, M., BRIGNARDELLO, E., LEONARDI, L., GATTO, V., GALLO, M., PIZZINI, A., BOCCUZZI, G."THE ANTIANDROGEN FLUTAMIDE INHIBITS GROWTH OF MCF-7 HUMAN BREAST-CANCER CELL-LINE". International Journal of Oncology 2.4 (1993): 653-656.
Chicago
DIMONACO, M., BRIGNARDELLO, E., LEONARDI, L., GATTO, V., GALLO, M., PIZZINI, A., BOCCUZZI, G."THE ANTIANDROGEN FLUTAMIDE INHIBITS GROWTH OF MCF-7 HUMAN BREAST-CANCER CELL-LINE". International Journal of Oncology 2, no. 4 (1993): 653-656. https://doi.org/10.3892/ijo.2.4.653