MOLECULAR CHARACTERIZATION OF SCL REARRANGEMENTS IN T-CELL ALL FROM INDIA AND EGYPT
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- Published online on: May 1, 1993 https://doi.org/10.3892/ijo.2.5.725
- Pages: 725-730
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Abstract
SCL gene rearrangement is the most common molecular lesion (25%) identified so far in T-cell acute lymphoblastic leukemia (T-ALL). Since the frequency of T-ALL appears to be relatively higher in developing countries, we wished to determine as to what fraction of T-ALL from this population harbor SCL rearrangements. We show in this study that although the overall frequency of SCL/SIL rearrangements in T-ALL is similar to the Western countries this is at the expense of increased type A rearrangements. Whether the paucity of type B rearrangements reflects a difference in disease etiology in this part of the world is to be determined.
