PROGNOSTIC VALUE OF ONCOPROTEINS FOR THE SURVIVAL OF PATIENTS WITH NONSMALL CELL LUNG CARCINOMAS
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- Published online on: May 1, 1993 https://doi.org/10.3892/ijo.2.5.767
- Pages: 767-772
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Abstract
Patients with non-small cell lung carcinomas whose tumors showed an overexpression of the oncogenes c-fos and c-N-ras at the protein level had significantly shorter survival times than those without overexpression of these oncogene products. (c-fos: p=0.0002, c-N-ras: p=0.002). Multivariate analysis showed that expression of proteins coded by c-fos and c-N-ras is a significant prognostic factor in addition to tumor staging and DNA ploidy. The prognostic value is improved by combining the expression of c-fos and c-N-ras products. A significant correlation between the expression of c-fos and c-N-ras products and the tumor take rate in nude mice was found.
