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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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June 2002 Volume 20 Issue 6

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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June 2002 Volume 20 Issue 6

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Article

The tumour suppressor p33ING1 does not enhance camptothecin-induced cell death in melanoma cells

  • Authors:
    • K.-John Cheung
    • Gang Li

  • View Affiliations / Copyright

    Affiliations: Division of Dermatology, Department of Medicine, University of British Columbia, and Vancouver Hospital and Health Sciences Centre, Vancouver, British Columbia V6H 3Z6, Canada
  • Pages: 1319-1322
    |
    Published online on: June 1, 2002
       https://doi.org/10.3892/ijo.20.6.1319
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Abstract

The tumour suppressor ING1 shares many biological functions with p53, such as cell cycle arrest, DNA repair, apoptosis, and chemosensitivity. Previous findings indicate that the isoform p24ING1 is capable of enhancing chemosensitivity in human fibroblasts. To investigate if the p33ING1 isoform is also involved in chemosensitivity, we overexpressed p33ING1 in melanoma cells and assessed for cell death after treatment with camptothecin. Results from the sulforhodamine B cell survival assay and flow cytometry analysis show no significant difference among cells transfected with vector, p33ING1, and antisense p33ING1. Furthermore, co-transfection of the p33ING1 and p53 constructs had no effect on the frequency of cell death, indicating that there is no synergistic effect between the two tumour suppressors in camptothecin-induced cell death in melanoma cells. This is in contrast to previously observed collaboration between p33ING1 and p53 in DNA repair and apoptosis. Taken together, we demonstrate that p33ING1 does not enhance camptothecin-induced cell death in melanoma cells.

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Copy and paste a formatted citation
Spandidos Publications style
Cheung K and Li G: The tumour suppressor p33ING1 does not enhance camptothecin-induced cell death in melanoma cells. Int J Oncol 20: 1319-1322, 2002.
APA
Cheung, K., & Li, G. (2002). The tumour suppressor p33ING1 does not enhance camptothecin-induced cell death in melanoma cells. International Journal of Oncology, 20, 1319-1322. https://doi.org/10.3892/ijo.20.6.1319
MLA
Cheung, K., Li, G."The tumour suppressor p33ING1 does not enhance camptothecin-induced cell death in melanoma cells". International Journal of Oncology 20.6 (2002): 1319-1322.
Chicago
Cheung, K., Li, G."The tumour suppressor p33ING1 does not enhance camptothecin-induced cell death in melanoma cells". International Journal of Oncology 20, no. 6 (2002): 1319-1322. https://doi.org/10.3892/ijo.20.6.1319
Copy and paste a formatted citation
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Spandidos Publications style
Cheung K and Li G: The tumour suppressor p33ING1 does not enhance camptothecin-induced cell death in melanoma cells. Int J Oncol 20: 1319-1322, 2002.
APA
Cheung, K., & Li, G. (2002). The tumour suppressor p33ING1 does not enhance camptothecin-induced cell death in melanoma cells. International Journal of Oncology, 20, 1319-1322. https://doi.org/10.3892/ijo.20.6.1319
MLA
Cheung, K., Li, G."The tumour suppressor p33ING1 does not enhance camptothecin-induced cell death in melanoma cells". International Journal of Oncology 20.6 (2002): 1319-1322.
Chicago
Cheung, K., Li, G."The tumour suppressor p33ING1 does not enhance camptothecin-induced cell death in melanoma cells". International Journal of Oncology 20, no. 6 (2002): 1319-1322. https://doi.org/10.3892/ijo.20.6.1319
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