Agaricus blazei Murill enhances doxorubicin-induced apoptosis in human hepatocellular carcinoma cells by NFκB-mediated increase of intracellular doxorubicin accumulation

Lee,Jong  Seok; Hong,Eock  Kee

doi:10.3892/ijo.2010.852

Agaricus blazei Murill enhances doxorubicin-induced apoptosis in human hepatocellular carcinoma cells by NFκB-mediated increase of intracellular doxorubicin accumulation

Authors:
- Jong Seok Lee
- Eock Kee Hong
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Affiliations: Department of Bioengineering and Technology, Kangwon National University, Chuncheon 200-701, Republic of Korea, College of Engineering, Department of Bioengineering and Technology, Kangwon National University, 192-1 Hyoja-2-dong, Chuncheon-si, Gangwon-do 200-701, Republic of Korea
Published online on: December 3, 2010 https://doi.org/10.3892/ijo.2010.852
Pages: 401-408

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Abstract

It has been demonstrated that the Agaricus blazei Murill (ABM) mushroom, which primarily consists of polysaccharides, possesses anti-tumor activities. However, the mechanisms by which ABM inhibits human hepatocellular carcinoma growth remain unknown. Our study demonstrates that ABM acts as an enhancer to sensitize doxorubicin (Dox)-mediated apoptotic signaling, and this sensitization can be achieved by enhancing intracellular Dox accumulation via the inhibition of NFκB activity. These findings suggest that ABM, when combined with low doses of Dox, has the potential to provide more efficient therapeutic effects against drug-resistant human hepatocellular carcinoma.