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Insight into the role of microRNAs in brain tumors (Review)

  • Authors:
    • Alessia Catania
    • Francesca Maira
    • Evangelia  Skarmoutsou
    • Fabio  D'Amico
    • Roger Abounader
    • Maria Clorinda Mazzarino

  • View Affiliations

  • Published online on: December 15, 2011     https://doi.org/10.3892/ijo.2011.1305
  • Pages: 605-624
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Abstract

MicroRNAs (MiRNAs) are small non-coding RNAs able to regulate gene expression at a posttranscriptional level. Recent evidence indicates that they play a crucial role in the initiation and progression of human cancers. In this review we briefly describe microRNA biogenesis and function, giving a more detailed account of the current state of knowledge concerning the role of microRNAs in brain tumors and stem-like tumor cells. MicroRNAs control brain tumor development by regulating multiple biological characteristics such as proliferation, invasion, differentiation and angiogenesis. Research in this field is rapidly spreading and encourages potential applications of microRNAs as diagnostic and prognostic tools, in addition to therapeutic targets and tools, to grant clinical benefits to patients suffering of brain tumors.

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Journal Cover

March 2012
Volume 40 Issue 3

Print ISSN: 1019-6439
Online ISSN:1791-2423

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  • Journal Metrics
  • Impact Factor: 4.5
  • Ranked Oncology
    (total number of cites)
  • CiteScore: 9.6
  • CiteScore Rank: Q1: #66/404 Oncology
  • Source Normalized Impact per Paper (SNIP): 0.88
  • SCImago Journal Rank (SJR): 1.099
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Spandidos Publications style
Catania A, Maira F, Skarmoutsou E, D'Amico F, Abounader R and Mazzarino MC: Insight into the role of microRNAs in brain tumors (Review). Int J Oncol 40: 605-624, 2012.
APA
Catania, A., Maira, F., Skarmoutsou, E., D'Amico, F., Abounader, R., & Mazzarino, M.C. (2012). Insight into the role of microRNAs in brain tumors (Review). International Journal of Oncology, 40, 605-624. https://doi.org/10.3892/ijo.2011.1305
MLA
Catania, A., Maira, F., Skarmoutsou, E., D'Amico, F., Abounader, R., Mazzarino, M. C."Insight into the role of microRNAs in brain tumors (Review)". International Journal of Oncology 40.3 (2012): 605-624.
Chicago
Catania, A., Maira, F., Skarmoutsou, E., D'Amico, F., Abounader, R., Mazzarino, M. C."Insight into the role of microRNAs in brain tumors (Review)". International Journal of Oncology 40, no. 3 (2012): 605-624. https://doi.org/10.3892/ijo.2011.1305