The novel resveratrol analogue HS-1793 induces apoptosis via the mitochondrial pathway in murine breast cancer cells

Kim,Hyoun-Ji; Yang,Kwang-Mo; Park,Yoo-Soo; Choi,Yoo-Jin; Yun,Ji-Hyeon; Son,Cheol-Hun; Suh,Hong-Suk; Jeong,Min-Ho; Jo,Wol-Soon

doi:10.3892/ijo.2012.1615

The novel resveratrol analogue HS-1793 induces apoptosis via the mitochondrial pathway in murine breast cancer cells

Authors:
- Hyoun-Ji Kim
- Kwang-Mo Yang
- Yoo-Soo Park
- Yoo-Jin Choi
- Ji-Hyeon Yun
- Cheol-Hun Son
- Hong-Suk Suh
- Min-Ho Jeong
- Wol-Soon Jo
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Affiliations: Department of Research Center, Dong Nam Institute of Radiological and Medical Sciences, Busan 619-953, Republic of Korea, Department of Biochemistry, College of Medicine, Pusan National University, Busan 609-735, Republic of Korea, Department of Microbiology, College of Medicine, Dong-A University, Busan 602-714, Republic of Korea
Published online on: August 31, 2012 https://doi.org/10.3892/ijo.2012.1615
Pages: 1628-1634
Copyright: © Kim et al. This is an open access article distributed under the terms of Creative Commons Attribution License [CC BY_NC 3.0].

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Abstract

Resveratrol (3,4',5 tri-hydroxystilbene), a natural plant polyphenol, has gained interest as a non-toxic chemopreventive agent capable of inducing tumor cell death in a variety of cancer types. Several studies were undertaken to obtain synthetic analogues of resveratrol with potent anticancer activity. The aim of the present study was to investigate the effect of HS-1793 as a new resveratrol analog on apoptosis via the mitochondrial pathway in murine breast cancer cells. A pharmacological dose (1.3-20 µM) of HS-1793 exerted a cytotoxic effect on murine breast cancer cells resulting in apoptosis. HS-1793-mediated cytotoxicity in FM3A cells by several apoptotic events including mitochondrial cytochrome c release, activation of caspase-3 and PARP occurred. In addition, HS-1793 induced collapse of ∆Ψm and enhanced AIF and Endo G release from mitochondria while undergoing apoptosis. These results demonstrate that the cytotoxicity by HS-1793 in FM3A cells can mainly be attributed to apoptosis via a mitochondrial pathway by caspase activation or contributions of AIF and Endo G.

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