Bcl-3 suppresses Tax-induced NF-κB activation through p65 nuclear translocation blockage in HTLV-1-infected cells

Wang,Jinheng; Li,Junying; Huang,Yanmei; Song,Xiangfeng; Niu,Zhiguo; Gao,Zhitao; Wang,Hui

doi:10.3892/ijo.2012.1685

Bcl-3 suppresses Tax-induced NF-κB activation through p65 nuclear translocation blockage in HTLV-1-infected cells

Authors:
- Jinheng Wang
- Junying Li
- Yanmei Huang
- Xiangfeng Song
- Zhiguo Niu
- Zhitao Gao
- Hui Wang
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Affiliations: Research Center for Immunology, Xinxiang Medical University, Xinxiang, Henan 453003, P.R. China, Henan Province Red Cross Blood Center, Zhengzhou, Henan 450000, P.R. China
Published online on: November 6, 2012 https://doi.org/10.3892/ijo.2012.1685
Pages: 269-276

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Abstract

Human T cell leukemia virus type 1 (HTLV-1) Tax-induced persistent activation of the NF-κB pathway is perceived as the primary cause of adult T cell leukemia (ATL), an aggressive leukemia caused by HTLV-1. Although elevated oncoprotein Bcl-3 levels are found in many HTLV-1-infected T cell lines and ATL cells, the role of Bcl-3 in the malignant progression caused by HTLV-1 retrovirus remains poorly understood. We confirmed, in the present study, that the Tax-induced NF-κB activation involves the regulation of Bcl-3. Both knockdown and overexpression of Bcl-3 inhibit the Tax-induced NF-κB activation. Similarly, excessive Bcl-3 inhibits the NF-κB/DNA binding activity and significantly decreases Tax-induced p65 nuclear translocation. The present results demonstrate the pleiotropic roles of Bcl-3 in Tax-induced NF-κB activation and indicate that a balance in the aberrant Bcl-3 expression may be established to play an important role in the maintenance of proliferation and inhibition of apoptosis in HTLV-1-infected and ATL cells.

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