The RANKL/RANK system as a therapeutic target for bone invasion by oral squamous cell carcinoma (Review)

  • Authors:
    • Eijiro Jimi
    • Masashi Shin
    • Hiroyuki Furuta
    • Yukiyo Tada
    • Jingo Kusukawa
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  • Published online on: January 23, 2013     https://doi.org/10.3892/ijo.2013.1794
  • Pages: 803-809
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Abstract

Squamous cell carcinomas (SCCs) of the gingiva frequently invade the mandible or maxilla; this invasion is associated with a worse prognosis. The bone destruction associated with carcinomal invasion is mediated by osteoclasts rather than directly by the carcinoma. Therefore, if the cellular and molecular mechanisms by which oral SCC regulates bone invasion were known, it could inform the development of new therapeutic targets. Recently, dysregulation of the functional equilibrium in the receptor activator of NF-κB ligand (RANKL)/RANK/osteoprotegerin (OPG) triad has been shown to be responsible for osteolysis associated with the development of malignant tumors in bone sites. Furthermore, the administration of OPG or soluble RANK prevents bone metastasis by cancer cells. In this review, we discuss recent findings indicating that bone invasion by oral SCC is mediated via RANKL/RANK and may be successfully prevented by RANKL inhibition.
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March 2013
Volume 42 Issue 3

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Spandidos Publications style
Jimi E, Shin M, Furuta H, Tada Y and Kusukawa J: The RANKL/RANK system as a therapeutic target for bone invasion by oral squamous cell carcinoma (Review). Int J Oncol 42: 803-809, 2013.
APA
Jimi, E., Shin, M., Furuta, H., Tada, Y., & Kusukawa, J. (2013). The RANKL/RANK system as a therapeutic target for bone invasion by oral squamous cell carcinoma (Review). International Journal of Oncology, 42, 803-809. https://doi.org/10.3892/ijo.2013.1794
MLA
Jimi, E., Shin, M., Furuta, H., Tada, Y., Kusukawa, J."The RANKL/RANK system as a therapeutic target for bone invasion by oral squamous cell carcinoma (Review)". International Journal of Oncology 42.3 (2013): 803-809.
Chicago
Jimi, E., Shin, M., Furuta, H., Tada, Y., Kusukawa, J."The RANKL/RANK system as a therapeutic target for bone invasion by oral squamous cell carcinoma (Review)". International Journal of Oncology 42, no. 3 (2013): 803-809. https://doi.org/10.3892/ijo.2013.1794