Selenium-binding protein 1 may decrease gastric cellular proliferation and migration

Zhang,Chenjing; Xu,Wen; Pan,Wensheng; Wang,Nana; Li,Guogang; Fan,Xiaoyuan; Xu,Xiang; Shen,Shengrong; Das,Undurti  N.

doi:10.3892/ijo.2013.1850

Selenium-binding protein 1 may decrease gastric cellular proliferation and migration

Authors:
- Chenjing Zhang
- Wen Xu
- Wensheng Pan
- Nana Wang
- Guogang Li
- Xiaoyuan Fan
- Xiang Xu
- Shengrong Shen
- Undurti N. Das
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Affiliations: Department of Gastroenterology, The Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310009, P.R. China, Department of Internal Medicine, Tianhe Hospital, Tianjin 300070, P.R. China, Department of Surgery, The Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310009, P.R. China, Department of Gastroenterology, Yinzhou People's Hospital, Ningbo 315040, P.R. China, Department of Pharmacy, The Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310009, P.R. China, Zhejiang University School of Biosystems Engineering and Food Science, Hangzhou 310000, P.R. China, UND Life Sciences, Shaker Heights, OH 44120, USA
Published online on: March 7, 2013 https://doi.org/10.3892/ijo.2013.1850
Pages: 1620-1629

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Abstract

It has been reported that suppression of selenium‑binding protein 1 (SBP1) occurs in many human malignancies which is considered to play an important role in cancer development and progression. Despite its importance in cancer, the function and factors that regulate its expression are not known. Using cell proliferation assays, immunochemical staining and immunoblotting and flow cytometry methods and in a xenograft model, we evaluated the role of SBP1 in proliferation, migration, senescence and chemoresistance of gastric cancer cells (SGC7901 and BGC823) to cisplatin. It was noted that diminished SBP1 expression increased gastric cancer cell proliferation and cell migration and decreased cisplatin-induced apoptosis while its overexpression produced the opposite effects. These results suggest that SBP1 plays a significant role in gastric cancer cell proliferation and modulates its response to anticancer drugs. These results suggest that SBP1 can serve as a potential target to suppress gastric cancer.

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