Open Access

Prognostic value of CAPZA1 overexpression in gastric cancer

  • Authors:
    • Young-Joon Lee
    • Sang-Ho Jeong
    • Soon-Chan Hong
    • Bok-Im Cho
    • Woo-Song Ha
    • Soon-Tae Park
    • Sang-Kyung Choi
    • Eun-Jung Jung
    • Young-Tae Ju
    • Chi-Young Jeong
    • Jae Won Kim
    • Chang Won Lee
    • Jiyun Yoo
    • Gyung Hyuck Ko
  • View Affiliations

  • Published online on: March 27, 2013     https://doi.org/10.3892/ijo.2013.1867
  • Pages: 1569-1577
  • Copyright: © Lee et al. This is an open access article distributed under the terms of Creative Commons Attribution License [CC BY_NC 3.0].

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Abstract

F-actin capping protein α1 subunit (CAPZA1) was previously identified in a proteomic analysis of human gastric cancer clinical specimens and selected for further study. The association between CAPZA1 overexpression, detected by immunohistochemistry, and clinicopathological features including survival were evaluated. In vitro gain-of-function and loss-of-function approaches were utilized to assess the function of CPAZA1 in malignancy. Univariate analysis revealed that poorly differentiated disease, according to the World Health Organization (WHO) classification, advanced T stage, positive lymph nodes, high TNM stage, D2 lymph node dissection, adjuvant chemotherapy and CAPZA1 underexpression were significantly associated with cancer-related death (p<0.05); however, only high TNM stage remained significantly associated by multivariate analysis (p<0.01). CAPZA1 overexpression was associated with well differentiated histology, smaller tumor size, lower T stage, absence of lymph node metastasis, lower TNM stage, lower recurrence rate and longer survival time, compared to CAPZA1 underexpression. In vitro, forced expression of CAPZA1 caused a significant decrease in gastric cancer cell migration and invasion, whereas CAPZA1 depletion had the opposite effect. The present study suggests that CAPZA1 could be a marker of good prognosis in gastric cancer and shows that CAPZA1 is associated with decreased cancer cell migration and invasion.
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May 2013
Volume 42 Issue 5

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Spandidos Publications style
Lee Y, Jeong S, Hong S, Cho B, Ha W, Park S, Choi S, Jung E, Ju Y, Jeong C, Jeong C, et al: Prognostic value of CAPZA1 overexpression in gastric cancer. Int J Oncol 42: 1569-1577, 2013.
APA
Lee, Y., Jeong, S., Hong, S., Cho, B., Ha, W., Park, S. ... Ko, G.H. (2013). Prognostic value of CAPZA1 overexpression in gastric cancer. International Journal of Oncology, 42, 1569-1577. https://doi.org/10.3892/ijo.2013.1867
MLA
Lee, Y., Jeong, S., Hong, S., Cho, B., Ha, W., Park, S., Choi, S., Jung, E., Ju, Y., Jeong, C., Kim, J. W., Lee, C. W., Yoo, J., Ko, G. H."Prognostic value of CAPZA1 overexpression in gastric cancer". International Journal of Oncology 42.5 (2013): 1569-1577.
Chicago
Lee, Y., Jeong, S., Hong, S., Cho, B., Ha, W., Park, S., Choi, S., Jung, E., Ju, Y., Jeong, C., Kim, J. W., Lee, C. W., Yoo, J., Ko, G. H."Prognostic value of CAPZA1 overexpression in gastric cancer". International Journal of Oncology 42, no. 5 (2013): 1569-1577. https://doi.org/10.3892/ijo.2013.1867