Telomerase regulation: A key to inhibition? (Review)
- Authors:
- Diego L. Mengual Gómez
- Hernán G. Farina
- Daniel E. Gómez
-
Affiliations: Laboratory of Molecular Oncology, Science and Technology Department, National University of Quilmes, Buenos Aires, Argentina - Published online on: September 16, 2013 https://doi.org/10.3892/ijo.2013.2104
- Pages: 1351-1356
This article is mentioned in:
Abstract
Blackburn EH: Structure and function of telomeres. Nature. 350:569–573. 1991. View Article : Google Scholar : PubMed/NCBI | |
Moyzis RK, Buckingham JM, Cram LS, et al: A highly conserved repetitive DNA sequence, (TTAGGG)n, present at the telomeres of human chromosomes. Proc Natl Acad Sci USA. 85:6622–6626. 1988. View Article : Google Scholar : PubMed/NCBI | |
Griffith JD, Comeau L, Rosenfield S, et al: Mammalian telomeres end in a large duplex loop. Cell. 97:503–514. 1999. View Article : Google Scholar : PubMed/NCBI | |
Greider CW: Telomeres do D-loop-T-loop. Cell. 97:419–422. 1999. View Article : Google Scholar : PubMed/NCBI | |
De Lange T: Shelterin: the protein complex that shapes and safeguards human telomeres. Genes Dev. 19:2100–2110. 2005.PubMed/NCBI | |
Neidle S: Human telomeric G-quadruplex: the current status of telomeric G-quadruplexes as therapeutic targets in human cancer. FEBS J. 277:1118–1125. 2010. View Article : Google Scholar : PubMed/NCBI | |
O’Sullivan RJ and Karlseder J: Telomeres: protecting chromosomes against genome instability. Nat Rev Mol Cell Biol. 11:171–181. 2010.PubMed/NCBI | |
Palm W and de Lange T: How shelterin protects mammalian telomeres. Annu Rev Genet. 42:301–334. 2008. View Article : Google Scholar : PubMed/NCBI | |
Smogorzewska A and de Lange T: Regulation of telomerase by telomeric proteins. Annu Rev Biochem. 73:177–208. 2004. View Article : Google Scholar : PubMed/NCBI | |
Greider CW and Blackburn EH: The telomere terminal transferase of Tetrahymena is a ribonucleoprotein enzyme with two kinds of primer specificity. Cell. 51:887–898. 1987. View Article : Google Scholar : PubMed/NCBI | |
Bryan TM and Reddel RR: Telomere dynamics and telomerase activity in in vitro immortalised human cells. Eur J Cancer. 33:767–773. 1997. View Article : Google Scholar : PubMed/NCBI | |
Broccoli D, Young JW and de Lange T: Telomerase activity in normal and malignant hematopoietic cells. Proc Natl Acad Sci USA. 92:9082–9086. 1995. View Article : Google Scholar : PubMed/NCBI | |
Ryan KM and Birnie GD: Cell-cycle progression is not essential for c-Myc to block differentiation. Oncogene. 14:2835–2843. 1997. View Article : Google Scholar : PubMed/NCBI | |
Wu KJ, Grandori C, Amacker M, et al: Direct activation of TERT transcription by c-MYC. Nat Genet. 21:220–224. 1999. View Article : Google Scholar : PubMed/NCBI | |
Greider CW and Blackburn EH: Identification of a specific telomere terminal transferase activity in Tetrahymena extracts. Cell. 43:405–413. 1985. View Article : Google Scholar : PubMed/NCBI | |
Mason M, Schuller A and Skordalakes E: Telomerase structure function. Curr Opin Struct Biol. 21:92–100. 2011. View Article : Google Scholar : PubMed/NCBI | |
Feng J, Funk WD, Wang SS, et al: The RNA component of human telomerase. Science. 269:1236–1241. 1995. View Article : Google Scholar : PubMed/NCBI | |
Morin GB: The human telomere terminal transferase enzyme is a ribonucleoprotein that synthesizes TTAGGG repeats. Cell. 59:521–529. 1989. View Article : Google Scholar : PubMed/NCBI | |
Ly H: Genetic and environmental factors influencing human diseases with telomere dysfunction. Int J Clin Exp Med. 2:114–130. 2009.PubMed/NCBI | |
Fu D and Collins K: Purification of human telomerase complexes identifies factors involved in telomerase biogenesis and telomere length regulation. Mol Cell. 28:773–785. 2007. View Article : Google Scholar : PubMed/NCBI | |
Venteicher AS, Meng Z, Mason PJ, Veenstra TD and Artandi SE: Identification of ATPases pontin and reptin as telomerase components essential for holoenzyme assembly. Cell. 132:945–957. 2008. View Article : Google Scholar : PubMed/NCBI | |
Zhong F, Savage SA, Shkreli M, et al: Disruption of telomerase trafficking by TCAB1 mutation causes dyskeratosis congenita. Genes Dev. 25:11–16. 2011. View Article : Google Scholar : PubMed/NCBI | |
Kelleher C, Teixeira MT, Forstemann K and Lingner J: Telomerase: biochemical considerations for enzyme and substrate. Trends Biochem Sci. 27:572–579. 2002. View Article : Google Scholar : PubMed/NCBI | |
De Boeck G, Forsyth RG, Praet M and Hogendoorn PC: Telomere-associated proteins: cross-talk between telomere maintenance and telomere-lengthening mechanisms. J Pathol. 217:327–344. 2009.PubMed/NCBI | |
Forsyth NR, Wright WE and Shay JW: Telomerase and differentiation in multicellular organisms: turn it off, turn it on, and turn it off again. Differentiation. 69:188–197. 2002. View Article : Google Scholar : PubMed/NCBI | |
Kilian A, Bowtell DD, Abud HE, et al: Isolation of a candidate human telomerase catalytic subunit gene, which reveals complex splicing patterns in different cell types. Hum Mol Genet. 6:2011–2019. 1997. View Article : Google Scholar : PubMed/NCBI | |
Ulaner GA, Hu JF, Vu TH, Giudice LC and Hoffman AR: Telomerase activity in human development is regulated by human telomerase reverse transcriptase (hTERT) transcription and by alternate splicing of hTERT transcripts. Cancer Res. 58:4168–4172. 1998. | |
Ulaner GA, Hu JF, Vu TH, Oruganti H, Giudice LC and Hoffman AR: Regulation of telomerase by alternate splicing of human telomerase reverse transcriptase (hTERT) in normal and neoplastic ovary, endometrium and myometrium. Int J Cancer. 85:330–335. 2000. View Article : Google Scholar : PubMed/NCBI | |
Cong YS, Wright WE and Shay JW: Human telomerase and its regulation. Microbiol Mol Biol Rev. 66:407–425. 2002. View Article : Google Scholar : PubMed/NCBI | |
Sawyers CL, McLaughlin J, Goga A, Havlik M and Witte O: The nuclear tyrosine kinase c-Abl negatively regulates cell growth. Cell. 77:121–131. 1994. View Article : Google Scholar : PubMed/NCBI | |
Kharbanda S, Kumar V, Dhar S, et al: Regulation of the hTERT telomerase catalytic subunit by the c-Abl tyrosine kinase. Curr Biol. 10:568–575. 2000. View Article : Google Scholar : PubMed/NCBI | |
Tomlinson RL, Ziegler TD, Supakorndej T, Terns RM and Terns MP: Cell cycle-regulated trafficking of human telomerase to telomeres. Mol Biol Cell. 17:955–965. 2006. View Article : Google Scholar : PubMed/NCBI | |
Jady BE, Richard P, Bertrand E and Kiss T: Cell cycle-dependent recruitment of telomerase RNA and Cajal bodies to human telomeres. Mol Biol Cell. 17:944–954. 2006. View Article : Google Scholar : PubMed/NCBI | |
Cioce M and Lamond AI: Cajal bodies: a long history of discovery. Annu Rev Cell Dev Biol. 21:105–131. 2005. View Article : Google Scholar : PubMed/NCBI | |
Wojtyla A, Gladych M and Rubis B: Human telomerase activity regulation. Mol Biol Rep. 38:3339–3349. 2011. View Article : Google Scholar | |
Jady BE, Bertrand E and Kiss T: Human telomerase RNA and box H/ACA scaRNAs share a common Cajal body-specific localization signal. J Cell Biol. 164:647–652. 2004. View Article : Google Scholar : PubMed/NCBI | |
Lukowiak AA, Narayanan A, Li ZH, Terns RM and Terns MP: The snoRNA domain of vertebrate telomerase RNA functions to localize the RNA within the nucleus. RNA. 7:1833–1844. 2001.PubMed/NCBI | |
Etheridge KT, Banik SS, Armbruster BN, et al: The nucleolar localization domain of the catalytic subunit of human telomerase. J Biol Chem. 277:24764–24770. 2002. View Article : Google Scholar : PubMed/NCBI | |
Yang Y, Chen Y, Zhang C, Huang H and Weissman SM: Nucleolar localization of hTERT protein is associated with telomerase function. Exp Cell Res. 277:201–209. 2002. View Article : Google Scholar : PubMed/NCBI | |
Aisner DL, Wright WE and Shay JW: Telomerase regulation: not just flipping the switch. Curr Opin Genet Dev. 12:80–85. 2002. View Article : Google Scholar : PubMed/NCBI | |
Collins K: Physiological assembly and activity of human telomerase complexes. Mech Ageing Dev. 129:91–98. 2008. View Article : Google Scholar : PubMed/NCBI | |
McEachern MJ, Krauskopf A and Blackburn EH: Telomeres and their control. Annu Rev Genet. 34:331–358. 2000. View Article : Google Scholar | |
Taggart AK, Teng SC and Zakian VA: Est1p as a cell cycle-regulated activator of telomere-bound telomerase. Science. 297:1023–1026. 2002. View Article : Google Scholar : PubMed/NCBI | |
Bachand F, Boisvert FM, Cote J, Richard S and Autexier C: The product of the survival of motor neuron (SMN) gene is a human telomerase-associated protein. Mol Biol Cell. 13:3192–3202. 2002. View Article : Google Scholar : PubMed/NCBI | |
Tomlinson RL, Abreu EB, Ziegler T, et al: Telomerase reverse transcriptase is required for the localization of telomerase RNA to cajal bodies and telomeres in human cancer cells. Mol Biol Cell. 19:3793–3800. 2008. View Article : Google Scholar : PubMed/NCBI | |
Li H: Unveiling substrate RNA binding to H/ACA RNPs: one side fits all. Curr Opin Struct Biol. 18:78–85. 2008. View Article : Google Scholar : PubMed/NCBI | |
Venteicher AS, Abreu EB, Meng Z, et al: A human telomerase holoenzyme protein required for Cajal body localization and telomere synthesis. Science. 323:644–648. 2009. View Article : Google Scholar : PubMed/NCBI | |
Cheng X and Roberts RJ: AdoMet-dependent methylation, DNA methyltransferases and base flipping. Nucleic Acids Res. 29:3784–3795. 2001. View Article : Google Scholar : PubMed/NCBI | |
Hamma T, Reichow SL, Varani G and Ferre-D’Amare AR: The Cbf5-Nop10 complex is a molecular bracket that organizes box H/ACA RNPs. Nat Struct Mol Biol. 12:1101–1107. 2005. View Article : Google Scholar : PubMed/NCBI | |
Pogacic V, Dragon F and Filipowicz W: Human H/ACA small nucleolar RNPs and telomerase share evolutionarily conserved proteins NHP2 and NOP10. Mol Cell Biol. 20:9028–9040. 2000. View Article : Google Scholar : PubMed/NCBI | |
Maiorano D, Brimage LJ, Leroy D and Kearsey SE: Functional conservation and cell cycle localization of the Nhp2 core component of H + ACA snoRNPs in fission and budding yeasts. Exp Cell Res. 252:165–174. 1999.PubMed/NCBI | |
Girard JP, Caizergues-Ferrer M and Lapeyre B: The SpGAR1 gene of Schizosaccharomyces pombe encodes the functional homologue of the snoRNP protein GAR1 of Saccharomyces cerevisiae. Nucleic Acids Res. 21:2149–2155. 1993. View Article : Google Scholar : PubMed/NCBI | |
Cossu F, Vulliamy TJ, Marrone A, Badiali M, Cao A and Dokal I: A novel DKC1 mutation, severe combined immunodeficiency (T+B-NK- SCID) and bone marrow transplantation in an infant with Hoyeraal-Hreidarsson syndrome. Br J Haematol. 119:765–768. 2002.PubMed/NCBI | |
Wong JM, Kyasa MJ, Hutchins L and Collins K: Telomerase RNA deficiency in peripheral blood mononuclear cells in X-linked dyskeratosis congenita. Hum Genet. 115:448–455. 2004.PubMed/NCBI | |
Vulliamy T, Beswick R, Kirwan M, et al: Mutations in the telomerase component NHP2 cause the premature ageing syndrome dyskeratosis congenita. Proc Natl Acad Sci USA. 105:8073–8078. 2008. View Article : Google Scholar : PubMed/NCBI | |
Walne AJ, Vulliamy T, Marrone A, et al: Genetic heterogeneity in autosomal recessive dyskeratosis congenita with one subtype due to mutations in the telomerase-associated protein NOP10. Hum Mol Genet. 16:1619–1629. 2007. View Article : Google Scholar : PubMed/NCBI | |
Heiss NS, Knight SW, Vulliamy TJ, et al: X-linked dyskeratosis congenita is caused by mutations in a highly conserved gene with putative nucleolar functions. Nat Genet. 19:32–38. 1998. View Article : Google Scholar : PubMed/NCBI | |
Meier UT: The many facets of H/ACA ribonucleoproteins. Chromosoma. 114:1–14. 2005. View Article : Google Scholar : PubMed/NCBI | |
Parry EM, Alder JK, Lee SS, et al: Decreased dyskerin levels as a mechanism of telomere shortening in X-linked dyskeratosis congenita. J Med Genet. 48:327–333. 2011. View Article : Google Scholar : PubMed/NCBI | |
Tomlinson RL, Li J, Culp BR, Terns RM and Terns MP: A Cajal body-independent pathway for telomerase trafficking in mice. Exp Cell Res. 316:2797–2809. 2010. View Article : Google Scholar : PubMed/NCBI | |
Lin J, Jin R, Zhang B, et al: Nucleolar localization of TERT is unrelated to telomerase function in human cells. J Cell Sci. 121:2169–2176. 2008. View Article : Google Scholar : PubMed/NCBI | |
Wong JM, Kusdra L and Collins K: Subnuclear shuttling of human telomerase induced by transformation and DNA damage. Nat Cell Biol. 4:731–736. 2002. View Article : Google Scholar : PubMed/NCBI | |
Gallardo F and Chartrand P: Telomerase biogenesis: The long road before getting to the end. RNA Biol. 5:212–215. 2008. View Article : Google Scholar : PubMed/NCBI | |
Collins K: The biogenesis and regulation of telomerase holoenzymes. Nat Rev Mol Cell Biol. 7:484–494. 2006. View Article : Google Scholar : PubMed/NCBI | |
Grozdanov PN, Roy S, Kittur N and Meier UT: SHQ1 is required prior to NAF1 for assembly of H/ACA small nucleolar and telomerase RNPs. RNA. 15:1188–1197. 2009. View Article : Google Scholar : PubMed/NCBI | |
Abreu E, Aritonovska E, Reichenbach P, et al: TIN2-tethered TPP1 recruits human telomerase to telomeres in vivo. Mol Cell Biol. 30:2971–2982. 2010. View Article : Google Scholar : PubMed/NCBI | |
Cifuentes-Rojas C and Shippen DE: Telomerase regulation. Mutat Res. 730:20–27. 2012. View Article : Google Scholar : PubMed/NCBI | |
Collins K and Mitchell JR: Telomerase in the human organism. Oncogene. 21:564–579. 2002. View Article : Google Scholar : PubMed/NCBI | |
Venteicher AS and Artandi SE: TCAB1: driving telomerase to Cajal bodies. Cell Cycle. 8:1329–1331. 2009. View Article : Google Scholar : PubMed/NCBI | |
Wang F, Podell ER, Zaug AJ, et al: The POT1-TPP1 telomere complex is a telomerase processivity factor. Nature. 445:506–510. 2007. View Article : Google Scholar : PubMed/NCBI | |
Xin H, Liu D, Wan M, et al: TPP1 is a homologue of ciliate TEBP-beta and interacts with POT1 to recruit telomerase. Nature. 445:559–562. 2007. View Article : Google Scholar : PubMed/NCBI | |
Shore D and Bianchi A: Telomere length regulation: coupling DNA end processing to feedback regulation of telomerase. EMBO J. 28:2309–2322. 2009. View Article : Google Scholar : PubMed/NCBI | |
Smogorzewska A, van Steensel B, Bianchi A, et al: Control of human telomere length by TRF1 and TRF2. Mol Cell Biol. 20:1659–1668. 2000. View Article : Google Scholar : PubMed/NCBI | |
Ancelin K, Brunori M, Bauwens S, et al: Targeting assay to study the cis functions of human telomeric proteins: evidence for inhibition of telomerase by TRF1 and for activation of telomere degradation by TRF2. Mol Cell Biol. 22:3474–3487. 2002. View Article : Google Scholar : PubMed/NCBI | |
Roth A, Harley CB and Baerlocher GM: Imetelstat (GRN163L)--telomerase-based cancer therapy. Recent Results Cancer Res. 184:221–234. 2010. View Article : Google Scholar : PubMed/NCBI | |
Chakraborty S, Ghosh U, Bhattacharyya NP, Bhattacharya RK and Roy M: Inhibition of telomerase activity and induction of apoptosis by curcumin in K-562 cells. Mutat Res. 596:81–90. 2006. View Article : Google Scholar : PubMed/NCBI | |
Mukherjee Nee Chakraborty S, Ghosh U, Bhattacharyya NP, Bhattacharya RK, Dey S and Roy M: Curcumin-induced apoptosis in human leukemia cell HL-60 is associated with inhibition of telomerase activity. Mol Cell Biochem. 297:31–39. 2007.PubMed/NCBI | |
Ramachandran C, Fonseca HB, Jhabvala P, Escalon EA and Melnick SJ: Curcumin inhibits telomerase activity through human telomerase reverse transcritpase in MCF-7 breast cancer cell line. Cancer Lett. 184:1–6. 2002. View Article : Google Scholar : PubMed/NCBI | |
Lee JH and Chung IK: Curcumin inhibits nuclear localization of telomerase by dissociating the Hsp90 co-chaperone p23 from hTERT. Cancer Lett. 290:76–86. 2010. View Article : Google Scholar : PubMed/NCBI | |
Moon DO, Kang SH, Kim KC, Kim MO, Choi YH and Kim GY: Sulforaphane decreases viability and telomerase activity in hepatocellular carcinoma Hep3B cells through the reactive oxygen species-dependent pathway. Cancer Lett. 295:260–266. 2010. View Article : Google Scholar |