Case-control study of the association between malignant brain tumours diagnosed between 2007 and 2009 and mobile and cordless phone use

Hardell,Lennart; Carlberg,Michael; Söderqvist,Fredrik; Mild,Kjell   Hansson

doi:10.3892/ijo.2013.2111

Case-control study of the association between malignant brain tumours diagnosed between 2007 and 2009 and mobile and cordless phone use

Authors:
- Lennart Hardell
- Michael Carlberg
- Fredrik Söderqvist
- Kjell Hansson Mild
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Affiliations: Department of Oncology, University Hospital, SE-701 85 Örebro, Sweden, Department of Radiation Sciences, Umeå University, SE-901 87 Umeå, Sweden
Published online on: September 24, 2013 https://doi.org/10.3892/ijo.2013.2111
Pages: 1833-1845
Copyright: © Hardell et al. This is an open access article distributed under the terms of Creative Commons Attribution License [CC BY_NC 3.0].

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Abstract

Previous studies have shown a consistent association between long-term use of mobile and cordless phones and glioma and acoustic neuroma, but not for meningioma. When used these phones emit radiofrequency electromagnetic fields (RF-EMFs) and the brain is the main target organ for the handheld phone. The International Agency for Research on Cancer (IARC) classified in May, 2011 RF-EMF as a group 2B, i.e. a ‘possible’ human carcinogen. The aim of this study was to further explore the relationship between especially long-term (>10 years) use of wireless phones and the development of malignant brain tumours. We conducted a new case-control study of brain tumour cases of both genders aged 18-75 years and diagnosed during 2007-2009. One population-based control matched on gender and age (within 5 years) was used to each case. Here, we report on malignant cases including all available controls. Exposures on e.g. use of mobile phones and cordless phones were assessed by a self-administered questionnaire. Unconditional logistic regression analysis was performed, adjusting for age, gender, year of diagnosis and socio-economic index using the whole control sample. Of the cases with a malignant brain tumour, 87% (n=593) participated, and 85% (n=1,368) of controls in the whole study answered the questionnaire. The odds ratio (OR) for mobile phone use of the analogue type was 1.8, 95% confidence interval (CI)=1.04‑3.3, increasing with >25 years of latency (time since first exposure) to an OR=3.3, 95% CI=1.6-6.9. Digital 2G mobile phone use rendered an OR=1.6, 95% CI=0.996-2.7, increasing with latency >15-20 years to an OR=2.1, 95% CI=1.2-3.6. The results for cordless phone use were OR=1.7, 95% CI=1.1-2.9, and, for latency of 15-20 years, the OR=2.1, 95% CI=1.2-3.8. Few participants had used a cordless phone for >20-25 years. Digital type of wireless phones (2G and 3G mobile phones, cordless phones) gave increased risk with latency >1-5 years, then a lower risk in the following latency groups, but again increasing risk with latency >15-20 years. Ipsilateral use resulted in a higher risk than contralateral mobile and cordless phone use. Higher ORs were calculated for tumours in the temporal and overlapping lobes. Using the meningioma cases in the same study as reference entity gave somewhat higher ORs indicating that the results were unlikely to be explained by recall or observational bias. This study confirmed previous results of an association between mobile and cordless phone use and malignant brain tumours. These findings provide support for the hypothesis that RF-EMFs play a role both in the initiation and promotion stages of carcinogenesis.

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1.	Baan R, Grosse Y, Lauby-Secretan B, et al: Carcinogenicity of radiofrequency electromagnetic fields. Lancet Oncol. 12:624–626. 2011. View Article : Google Scholar : PubMed/NCBI
2.	IARC Monographs on the Evaluation of Carcinogenic Risks to Humans. Non-ionizing radiation, Part 2: Radiofrequency electromagnetic fields. 102:IARCPress; Lyon: 2013, http://monographs.iarc.fr/ENG/Monographs/vol102/mono102.pdf. Accessed July 11, 2013.
3.	Interphone Study Group: Brain tumour risk in relation to mobile telephone use: results of the INTERPHONE international case-control study. Int J Epidemiol. 39:675–694. 2010. View Article : Google Scholar : PubMed/NCBI
4.	Hardell L, Carlberg M and Hansson Mild K: Methodological aspects of epidemiological studies on the use of mobile phones and their association with brain tumors. Open Env Sciences. 2:54–61. 2008. View Article : Google Scholar
5.	Hardell L, Carlberg M and Hansson Mild K: Use of mobile phones and cordless phones is associated with increased risk for glioma and acoustic neuroma. Pathophysiology. 20:85–110. 2013. View Article : Google Scholar : PubMed/NCBI
6.	Cardis E and Sadetzki S: Indications of possible brain tumour risk in mobile phone studies: should we be concerned? Occup Environ Med. 68:169–171. 2011. View Article : Google Scholar : PubMed/NCBI
7.	Wilén J, Sandström M and Hansson Mild K: Subjective symptoms among mobile phone users - a consequence of absorption of radiofrequency fields? Bioelectromagnetics. 24:152–159. 2003.PubMed/NCBI
8.	Hardell L, Hansson Mild K, Påhlson A and Hallquist A: Ionizing radiation, cellular telephones and the risk for brain tumours. Eur J Cancer Prev. 10:523–529. 2001. View Article : Google Scholar : PubMed/NCBI
9.	Cardis E, Deltour I, Mann S, et al: Distribution of RF energy emitted by mobile phones in anatomical structures of the brain. Phys Med Biol. 53:2771–2783. 2008. View Article : Google Scholar : PubMed/NCBI
10.	Hardell L, Näsman Å, Påhlson A, Hallquist A and Hansson Mild K: Use of cellular telephones and the risk for brain tumours: A case-control study. Int J Oncol. 15:113–116. 1999.PubMed/NCBI
11.	Hardell L, Hallquist A, Hansson Mild K, Carlberg M, Påhlson A and Lilja A: Cellular and cordless telephones and the risk for brain tumours. Eur J Cancer Prev. 11:377–386. 2002. View Article : Google Scholar : PubMed/NCBI
12.	Hardell L, Carlberg M and Hansson Mild K: Case-control study of the association between the use of cellular and cordless telephones and malignant brain tumors diagnosed during 2000–2003. Environ Res. 100:232–241. 2006.
13.	Hardell L, Carlberg M and Hansson Mild K: Pooled analysis of two case-control studies on use of cellular and cordless telephones and the risk for malignant brain tumours diagnosed in 1997–2003. Int Arch Occup Environ Health. 79:630–639. 2006.
14.	Hardell L, Carlberg M and Hansson Mild K: Epidemiological evidence for an association between use of wireless phones and tumor diseases. Pathophysiology. 16:113–122. 2009. View Article : Google Scholar : PubMed/NCBI
15.	Hardell L, Carlberg M and Hansson Mild K: Pooled analysis of case-control studies on malignant brain tumours and the use of mobile and cordless phones including living and deceased subjects. Int J Oncol. 38:1465–1474. 2011. View Article : Google Scholar : PubMed/NCBI
16.	Carlberg M and Hardell L: On the association between glioma, wireless phones, heredity and ionising radiation. Pathophysiology. 19:243–252. 2012. View Article : Google Scholar : PubMed/NCBI
17.	Interphone Study Group: Acoustic neuroma risk in relation to mobile telephone use: results of the INTERPHONE international case-control study. Cancer Epidemiol. 35:453–464. 2011. View Article : Google Scholar : PubMed/NCBI
18.	Post-och Telestyrelsen: Svensk Telemarknad 2010. http://www.statistik.pts.se/pts2011/FILES/RAPPORTER/2010/Telemarknad_2010.pdf. Accessed July 11, 2013.
19.	Hardell L, Carlberg M and Gee D: Mobile phone use and brain tumour risk: early warnings, early actions? Late Lessons from Early Warnings, Part 2. European Environment Agency; Copenhagen: 2013, http://www.eea.europa.eu/publications/late-lessons-2/late-lessons-chapters/late-lessons-ii-chapter-21/at_download/file. Accessed July 11, 2013.
20.	Harrell FE Jr: Regression Modeling Strategies With Application to Linear Models, Logistic Regression and Survival Analysis. Springer; New York, NY: pp. 20–26. 2001
21.	Hardell L: Relation of soft tissue sarcoma, malignant lymphoma, and colon cancer to phenoxy acids, chlorophenols and other agents. Scand J Work Environ Health. 7:119–130. 1981. View Article : Google Scholar : PubMed/NCBI
22.	Carlberg M, Söderqvist F, Hansson Mild K and Hardell L: Meningioma patients diagnosed 2007–2009 and the association with use of mobile and cordless phones: a case-control study. Environ Health. 12:602013.
23.	Hardell L, Carlberg M, Söderqvist F and Hansson Mild K: Pooled analysis of case-control studies on acoustic neuroma diagnosed 1997–2003 and 2007–2009 and use of mobile and cordless phones. Int J Oncol. 43:1036–1044. 2013.
24.	Muscat JE, Malkin MG, Thompson S, et al: Handheld cellular telephone use and risk of brain cancer. JAMA. 284:3001–3007. 2000. View Article : Google Scholar : PubMed/NCBI
25.	Inskip PD, Tarone RE, Hatch EE, et al: Cellular-telephone use and brain tumors. N Engl J Med. 344:79–86. 2001. View Article : Google Scholar : PubMed/NCBI
26.	Auvinen A, Hietanen M, Luukkonen R and Koskela RS: Brain tumors and salivary gland cancers among cellular telephone users. Epidemiology. 13:356–359. 2002. View Article : Google Scholar : PubMed/NCBI
27.	Söderqvist F, Carlberg M and Hardell L: Review of four publications on the Danish cohort study on mobile phone subscribers and risk of brain tumours. Rev Environ Health. 27:51–58. 2012.PubMed/NCBI
28.	Kundi M: Essential problems in the interpretation of epidemiologic evidence for an association between mobile phone use and brain tumours. C R Physique. 11:556–563. 2010. View Article : Google Scholar
29.	Ohgaki H, Dessen P, Jourde B, et al: Genetic pathways of glioblastoma: a population-based study. Cancer Res. 64:6892–6899. 2004. View Article : Google Scholar : PubMed/NCBI
30.	Hardell L: Soft-tissue sarcoma and exposure to phenoxy acids - A clinical observation. Läkartidningen. 74:2853–2854. 1977.(In Swedish).
31.	Hardell L: Malignant lymphoma of histiocytic type and exposure to phenoxyacetic acids or chlorophenols. Lancet. 1:55–56. 1979. View Article : Google Scholar : PubMed/NCBI
32.	Hardell L and Sandström A: Case-control study: soft-tissue sarcomas and exposure to phenoxyacetic acids or chlorophenols. Br J Cancer. 39:711–717. 1979. View Article : Google Scholar : PubMed/NCBI
33.	Hardell L, Eriksson M, Lenner P and Lundgren E: Malignant lymphoma and exposure to chemicals, especially organic solvents, chlorophenols and phenoxy acids: a case-control study. Br J Cancer. 43:169–176. 1981. View Article : Google Scholar : PubMed/NCBI
34.	Hardell L, Carlberg M and Hansson Mild K: Mobile phone use and the risk for malignant brain tumors: a case-control study on deceased cases and controls. Neuroepidemiology. 35:109–114. 2010. View Article : Google Scholar : PubMed/NCBI
35.	Bergenheim T, Malmström A, Bolander H, et al: Registration on regional basis of patients with primary brain tumors. Regional differences disclosed. Läkartidningen. 104:332–341. 2007.(In Swedish).
36.	Barlow L, Westergren K, Holmberg L and Talbäck M: The completeness of the Swedish Cancer Register: a sample survey for year 1998. Acta Oncol. 48:27–33. 2009.PubMed/NCBI
37.	Hardell L and Carlberg M: Use of mobile and cordless phones and survival of patients with glioma. Neuroepidemiology. 40:101–108. 2013. View Article : Google Scholar : PubMed/NCBI
38.	Ohgaki H and Kleihues P: Population-based studies on incidence, survival rates, and genetic alterations in astrocytic and oligodendroglial gliomas. J Neuropathol Exp Neurol. 64:479–489. 2005.PubMed/NCBI
39.	Vrijheid M, Cardis E, Armstrong BK, et al: Validation of short term recall of mobile phone use for the Interphone study. Occup Environ Med. 63:237–243. 2006. View Article : Google Scholar : PubMed/NCBI
40.	Vrijheid M, Deltour I, Krewski D, Sanchez M and Cardis E: The effects of recall errors and of selection bias in epidemiologic studies of mobile phone use and cancer risk. J Expo Sci Environ Epidemiol. 16:371–384. 2006. View Article : Google Scholar : PubMed/NCBI
41.	Preston-Martin S and Mack W: Neoplasms of the nervous system. Cancer Epidemiology and Prevention. Schottenfeld D and Fraumeni JF Jr: Oxford University Press; New York, NY: pp. 1231–1281. 1996
42.	Lai H and Singh NP: Melatonin and a spin-trap compound block radiofrequency electromagnetic radiation-induced DNA strand breaks in rat brain cells. Bioelectromagnetics. 18:446–454. 1997. View Article : Google Scholar : PubMed/NCBI
43.	Phillips JL, Singh NP and Lai H: Electromagnetic fields and DNA damage. Pathophysiology. 16:79–88. 2009. View Article : Google Scholar : PubMed/NCBI
44.	Liu C, Duan W, Xu S, et al: Exposure to 1800 MHz radiofrequency electromagnetic radiation induces oxidative DNA base damage in a mouse spermatocyte-derived cell line. Toxicol Lett. 218:2–9. 2013. View Article : Google Scholar : PubMed/NCBI
45.	Collins VP: Gliomas. Cancer Surv. 32:37–51. 1998.