Preoperative treatment of locally advanced esophageal carcinoma (Review)
- Authors:
- Michele Orditura
- Gennaro Galizia
- Alessio Fabozzi
- Eva Lieto
- Valentina Gambardella
- Floriana Morgillo
- Gian Mattia Del Genio
- Landino Fei
- Natale Di Martino
- Andrea Renda
- Fortunato Ciardiello
- Ferdinando De Vita
-
Affiliations: Division of Medical Oncology, ‘F. Magrassi - A. Lanzara’ Department of Clinical and Experimental Medicine and Surgery, Second University of Naples, School of Medicine, Naples, Italy, Division of Surgery, ‘F. Magrassi - A. Lanzara’ Department of Clinical and Experimental Medicine and Surgery, Second University of Naples, School of Medicine, Naples, Italy, Division of General Surgery, University of Naples Federico II, School of Medicine, Naples, Italy - Published online on: October 2, 2013 https://doi.org/10.3892/ijo.2013.2118
- Pages: 1745-1753
This article is mentioned in:
Abstract
Ferlay J, Autier P, Boniol M, Heanue M, Colombert M and Boyle P: Estimates of the cancer incidence and mortality in Europe in 2006. Ann Oncol. 18:581–592. 2007. View Article : Google Scholar : PubMed/NCBI | |
Siegel R, Naishadham D and Jemal A: Cancer statistics, 2012. CA Cancer J Clin. 62:10–29. 2012. View Article : Google Scholar | |
AIRTUM: http://www.registri-tumori.it/cms/. Accessed. | |
Cooper JS, Guo MD, Herskovich A, et al: Chemoradiotherapy of locally advanced esophageal cancer: long-term follow-up of a prospective randomized trial (RTOG 85-01); Radiation Therapy Oncology Group. JAMA. 281:1623–1627. 1998.PubMed/NCBI | |
Philip PA and Ajani JA: Has combined modality therapy improved the outlook in carcinoma of the esophagus? Oncology. 8:37–42. 1994.PubMed/NCBI | |
Parkin DM, Bray FI and Devesa SS: Cancer burden in the year 2000. The global picture. Eur J Cancer. 37(Suppl 8): 64–66. 2001. | |
Ries LAG, Melbert D, Krapcho M, et al: SEER Cancer Statistics Review, 1975–2005. National Cancer Institute; Bethesda, MD: Available from URL: http://seer.cancer.gov/csr/1975_2005/, based on November 2007 SEER data submission, posted to SEER web site, 2008. | |
Siewert JR, Stein HJ, Feith M, Bruecher BL, Barthels H and Fink U: Histologic tumor type is an independent prognostic parameter in esophageal cancer: lessons from more than 1,000 consecutive resections at single center in the Western world. Ann Surg. 234:360–369. 2001. View Article : Google Scholar | |
Khushalani N: Cancer of the esophagus and stomach. Mayo Clin Proc. 83:712–722. 2008. View Article : Google Scholar : PubMed/NCBI | |
Wijnhoven BP, van Lanschot JJ, Tilanus HW, Steyerberg EW and van der Gaast A: Neoadjuvant chemoradiotherapy for esophageal cancer: a review of meta-analyses. World J Surg. 33:2606–2614. 2009. View Article : Google Scholar : PubMed/NCBI | |
Kelsen DP, Ginsberg R, Pajak TF, et al: Chemotherapy followed by surgery compared with surgery alone for localized esophageal cancer. N Engl J Med. 339:1979–1984. 1998. View Article : Google Scholar : PubMed/NCBI | |
Kelsen DP, Winter KA, Gunderson LL, et al: Long-term result of RTOG trial 8911 (USA Intergroup 113): a random assignment trial comparison of chemotherapy followed by surgery compared with surgery alone for esophageal cancer. J Clin Oncol. 25:3719–3725. 2007. View Article : Google Scholar : PubMed/NCBI | |
Medical Research Council: Surgical resection with or without preoperative chemotherapy in oesophageal cancer: a randomized controlled trial. Lancet. 359:1727–1733. 2007. | |
Allum WH, Fogarty PJ, Stenning SP and Langley RE; for the NCRI Upper GI Cancer Clinical Studies Group: Long term results of the MRC OEO2 randomized trial of surgery with or without preoperative chemotherapy in resectable esophageal cancer. Proc Gastrointest Cancers Symp. 2008.9a2008. | |
Sjoquist KM, Burmeister BH, Smithers BM, et al: Survival after neoadjuvant chemotherapy or chemoradiotherapy for resectable oesophageal carcinoma: an updated meta-analysis. Lancet Oncology. 12:681–692. 2011. View Article : Google Scholar : PubMed/NCBI | |
Arnott SJ, Duncan W, Ginoux M, et al: Preoperative radiotherapy in esophageal carcinoma: a meta-analysis using individual patient data (Oesophageal Cancer Collaborative Group). Int J Radiat Oncol Biol Phys. 41:579–583. 1998. View Article : Google Scholar | |
Ku GY and Ilson DH: Preoperative therapy in esophageal cancer. Clin Adv Hematol Oncol. 6:371–379. 2008.PubMed/NCBI | |
De Vita F, Di Martino N, Orditura M, et al: Preoperative chemoradiotherapy for squamous cell carcinoma and adenocarcinoma of the esophagus. A phase II study. Chest. 122:1302–1308. 2009.PubMed/NCBI | |
Nabeya Y, Ochiai T, Matsubara H, et al: Neoadjuvant chemoradiotherapy followed by esophagectomy for initially resectable squamous cell carcinoma of the esophagus with multiple lymph node metastasis. Dis Esophagus. 18:388–397. 2005. View Article : Google Scholar : PubMed/NCBI | |
Smith TJ, Ryan LM, Douglas HO Jr, et al: Combined chemoradiotherapy vs. radiotherapy alone for early stage squamous cell carcinoma of the esophagus: a study of Eastern Cooperative Oncology Group. Int J Radiat Oncol Biol Phys. 42:269–276. 1998. View Article : Google Scholar : PubMed/NCBI | |
Ajani JA: Current status of new drugs and multidisciplinary approaches in patients with carcinoma of the esophagus. Chest. 113(Suppl): S112–S119. 1998. View Article : Google Scholar : PubMed/NCBI | |
Walsh TN, Noonan N, Hollywood D, Kelly A, Keeling N and Hennessy TP: A comparison of multimodal therapy and surgery for esophageal adenocarcinoma. N Engl J Med. 335:462–467. 1996. View Article : Google Scholar : PubMed/NCBI | |
Urba SG, Orringer MB, Turrisi A, Iannettoni M, Forastiere A and Strawderman M: Randomized trial of preoperative chemoradiation vs. surgery alone in patients with locoregional esophageal carcinoma. J Clin Oncol. 19:305–313. 2001.PubMed/NCBI | |
Bosset JF, Gignoux M, Triboulet JP, et al: Chemoradiotherapy followed by surgery compared with surgery alone in squamous-cell cancer of the esophagus. N Engl J Med. 337:161–167. 1997. View Article : Google Scholar : PubMed/NCBI | |
Burmeister BH, Smithers BM, Gebski V, et al: Surgery alone vs. chemoradiotherapy followed by surgery for resectable cancer of the oesophagus: a randomized controlled phase III trial. Lancet Oncol. 6:659–668. 2005. View Article : Google Scholar : PubMed/NCBI | |
Stahl M, Walz MK, Stuschke M, et al: Phase III comparison of preoperative chemotherapy compared with chemoradiotherapy in patients with locally advanced adenocarcinoma of the esophagogastric junction. J Clin Oncol. 27:851–856. 2009. View Article : Google Scholar : PubMed/NCBI | |
van Hagen P, Hulshof MC, van Lanschot JJ, et al: Preoperative chemoradiotherapy for esophageal or junctional cancer. N Engl J Med. 366:2074–2084. 2012. | |
Urschel JD and Vasan H: A meta-analysis of randomized controlled trials that compared neoadjuvant chemoradiation and surgery to surgery alone for resectable esophageal cancer. Am J Surg. 185:538–543. 2003. View Article : Google Scholar | |
Gebsky V, Burnmeister B, Smithers BM, Foo K and Zalcberg J; Simes J for the Australasian Gastro-Intestinal Trials Group: Survival benefits from neoadjuvant chemoradiotherapy or chemotherapy in oesophageal carcinoma: a meta-analysis. Lancet Oncol. 8:226–234. 2007. View Article : Google Scholar : PubMed/NCBI | |
Kranzfelder M, Schuster T, Geinitz H, Friess H and Biichler P: Meta-analysis of neoadjuvant treatment modalities and definitive non-surgical therapy for oesophageal squamous cell cancer. Br J Surg. 98:768–783. 2011. View Article : Google Scholar : PubMed/NCBI | |
Tabernero J, Macarulla T, Ramos FJ and Baselga J: Novel targeted therapies in the treatment of gastric and esophageal cancer. Ann Oncol. 16:1740–1748. 2005. View Article : Google Scholar : PubMed/NCBI | |
Itakura Y, Sasano H, Shiga C, Furukawa Y, Shiga K, Mori S and Nagura H: Epidermal growth factor receptor overexpression in esophageal carcinoma. An immunohistochemical study correlated with clinicopathologic findings and DNA amplification. Cancer. 74:795–804. 1994. View Article : Google Scholar | |
Pande AU, Iyer RV, Rani A, et al: Epidermal growth factor receptor-directed therapy in esophageal cancer. Oncology. 73:281–289. 2007. View Article : Google Scholar : PubMed/NCBI | |
Wang KL, Wu TT, Choi IS, et al: Expression of epidermal growth factor receptor in esophageal and esophagogastric junction adenocarcinomas. Cancer. 109:658–667. 2007. View Article : Google Scholar : PubMed/NCBI | |
De Vita F, Orditura M, Martinelli E, et al: A multicentric phase II study of induction chemotherapy with FOLFOX-4 and cetuximab followed by radiation and cetuximab in locally advanced oesophageal cancer. Br J Cancer. 104:427–432. 2011.PubMed/NCBI | |
Ciardiello F and Tortora G: Epidermal growth factor receptor (EGFR) antagonists in cancer treatment. N Engl J Med. 358:1160–1174. 2008. View Article : Google Scholar | |
Langer CJ: Emerging role of epidermal growth factor receptor inhibition in therapy for advanced malignancy: focus on NSCLC. Int J Radiat Oncol Biol Phys. 58:991–1002. 2004. View Article : Google Scholar : PubMed/NCBI | |
Raben D, Helfrich B and Bunn PA Jr: Targeted therapies for non-small-cell lung cancer: biology, rationale, and preclinical results from a radiation oncology perspective. Int J Radiat Oncol Biol Phys. 59(Suppl 2): 27–38. 2004. View Article : Google Scholar : PubMed/NCBI | |
Safran H, Suntharalingam M, Dipetrillo T, et al: Cetuximab with concurrent chemoradiation for esophagogastric cancer: assessment of toxicity. Int J Radiat Oncol Biol Phys. 70:391–395. 2008. View Article : Google Scholar : PubMed/NCBI | |
Sgroi MM, Hanna NH, McCollum AD, et al: Preoperative cetuximab and radiation (XRT) for patients (pts) with surgically resectable esophageal and gastroesophageal cancer (GE) junction carcinomas: a pilot study from the Hoosier Oncology Groop and the University of Texas-Southwestern. J Clin Oncol. 26(Suppl): S22945642008. | |
Ruhstaller T, Pless M, Dietrich D, et al: Cetuximab in combination with chemoradiotherapy before surgery in patients with resectable, locally advanced esophageal carcinoma: a prospective, multicenter phase IB/II Trial (SAKK 75/06). J Clin Oncol. 29:626–631. 2011. View Article : Google Scholar | |
Hurt CN, Nixon LS, Griffiths GO, et al: SCOPE 1: a randomized phase II/III multicenter clinical trial of definitive chemoradiation with or without cetuximab, in carcinoma of the esophagus. BMC Cancer. 11:4662011. View Article : Google Scholar : PubMed/NCBI | |
Paclitaxel, cisplatin, and radiation therapy with or without cetuximab in treating patients with locally advanced esophageal cancer. April 9–2008, http://clinicaltrial.gov/ct2/show/NCT00655876. | |
Baumann M, Krause M, Dikomey E, Dittmann K, Dörr W, Kasten-Pisula U and Rodemann HP: EGFR-targeted anti-cancer drugs in radiotherapy: preclinical evaluation of mechanisms. Radiother Oncol. 83:238–248. 2007. View Article : Google Scholar : PubMed/NCBI | |
Dobelbower MC, Russo SM, Raisch KP, et al: Epidermal growth factor receptor tyrosine kinase inhibitor, erlotinib, and concurrent 5-fluorouracil, cisplatin and radiotherapy for patients with esophageal cancer: a phase I study. Anticancer Drugs. 17:95–102. 2006. View Article : Google Scholar | |
Rodriguez CP, Adelstein DJ, Rybicki LA, et al: Single-arm phase II study of multiagent concurrent chemoradiotherapy and gefitinib in locoregionally advanced squamous cell carcinoma of the head and neck. Head Neck. 34:1517–1523. 2012. View Article : Google Scholar : PubMed/NCBI | |
Ross JS and McKenna BJ: The HER-2/neu oncogene in tumors of the gastrointestinal tract. Cancer Invest. 19:554–568. 2001. View Article : Google Scholar : PubMed/NCBI | |
Tew WP, Kelsen DP and Ilson DH: Targeted therapies for esophageal cancer. Oncologist. 10:590–601. 2005. View Article : Google Scholar : PubMed/NCBI | |
Nahta R, Hortobagyi GN and Esteva FJ: Growth factor receptors in breast cancer: potential for therapeutic intervention. Oncologist. 8:5–17. 2003. View Article : Google Scholar : PubMed/NCBI | |
Pegram MD, Lopez A, Konecny G and Slamon DJ: Trastuzumab and chemotherapeutics: drug interactions and synergies. Semin Oncol. 27(Suppl 11): 21–25; discussion 92–100. 2000.PubMed/NCBI | |
Ma BB, Bristow RG, Kim J, et al: Combined-modality treatment of solid tumors using radiotherapy and molecular targeted agents. J Clin Oncol. 21:2760–2776. 2003. View Article : Google Scholar : PubMed/NCBI | |
Safran H, Di Petrillo T, Nadeem A, et al: Trastuzumab, paclitaxel, cisplatin, and radiation for adenocarcinoma of the esophagus: a phase I study. Cancer Invest. 22:670–677. 2004. View Article : Google Scholar : PubMed/NCBI | |
Bang YJ, Van Cutsem E, Feyereislova A, et al: Trastuzumab in combination with chemotherapy vs. chemotherapy alone for treatment of HER2-positive advanced gastric or gastroesophageal junction cancer (ToGA): a phase 3, open-label, randomised controlled trial. Lancet. 376:687–697. 2010. View Article : Google Scholar | |
Kerbel R and Folkman J: Clinical translation of angiogenesis inhibitors. Nat Rev Cancer. 2:727–739. 2002. View Article : Google Scholar : PubMed/NCBI | |
Folkman J: Angiogenesis and angiogenesis inhibition: an overview. EXS. 79:1–8. 1997.PubMed/NCBI | |
Shih CH, Ozawa S, Ando N, et al: Vascular endothelial growth factor expression predicts outcome and lymph node metastasis in squamous cell carcinoma of the esophagus. Clin Cancer Res. 6:1161–1168. 2000.PubMed/NCBI | |
Kleespies A, Guba M, Jauch KW, et al: Vascular endothelial growth factor in esophageal cancer. J Surg Oncol. 87:95–104. 2004. View Article : Google Scholar : PubMed/NCBI | |
Gerber HP and Ferrara N: Pharmacology and pharmacodynamics of bevacizumab as monotherapy or in combination with cytotoxic therapy in preclinical studies. Cancer Res. 65:671–680. 2005.PubMed/NCBI | |
Shah MA, Ramanathan RK, Ilson DH, et al: Multicenter phase II study of irinotecan, cisplatin, and bevacizumab in patients with metastatic gastric or gastroesophageal junction adenocarcinoma. J Clin Oncol. 24:5201–5206. 2006. View Article : Google Scholar : PubMed/NCBI | |
Bendell JC, Meluch A, Peyton J, et al: A phase II trial of preoperative concurrent chemotherapy/radiation therapy plus bevacizumab/erlotinib in the treatment of localized esophageal cancer. Clin Adv Hematol Oncol. 10:430–437. 2012. | |
Ajani JA, Correa AM, Hofstetter WL, et al: Clinical parameters model for predicting pathologic complete response following preoperative chemoradiation in patients with esophageal cancer. Ann Oncol. 10:2638–2642. 2012. View Article : Google Scholar | |
Ngamruengphong S, Sharma VK, Nguyen B and Das A: Assessment of response to neoadjuvant therapy in esophageal cancer: an updated systemic review of diagnostic accuracy of endoscopic ultrasonography and fluorodeoxyglucose positron emission tomography. Dis Esophagus. 23:216–231. 2010. View Article : Google Scholar | |
Weber WA, Ott K, Becker K, et al: Prediction of response to preoperative chemotherapy in adenocarcinomas of the esophagogastric junction by metabolic imaging. J Clin Oncol. 19:3058–3065. 2001.PubMed/NCBI | |
Ott K, Weber WA, Lordick F, et al: Metabolic imaging predicts response, survival and recurrence in adenocarcinomas of the esophagogastric junction. J Clin Oncol. 24:4692–4698. 2006. View Article : Google Scholar : PubMed/NCBI | |
Power DG and Ilson DH: Integration of targeted agents in the neo-adjuvant treatment of gastro-esophageal cancers. Ther Adv Med Oncol. 1:145–165. 2009. View Article : Google Scholar : PubMed/NCBI | |
Lordick F, Ott K, Krause BJ, et al: PET to assess early metabolic response and to guide treatment of adenocarcinoma of the oesophagogastric junction: the MUNICON phase II trial. Lancet Oncol. 8:797–805. 2007. View Article : Google Scholar : PubMed/NCBI | |
Orditura M, Galizia G, Morgillo F, et al: Complete response to preoperative chemoradiation and survival in esophageal cancer: a pooled analysis of three single-institution phase II trials. Dis Esophagus. 25:130–136. 2012. View Article : Google Scholar : PubMed/NCBI | |
Ajani JA, Ilson DH, Daugherty K, et al: Activity of taxol in patients with squamous cell carcinoma and adenocarcinoma of the esophagus. J Nat Cancer Inst. 86:1086–1091. 1994. View Article : Google Scholar : PubMed/NCBI | |
Lin CC and Papadopoulos KP: Novel target therapies for advanced esophageal cancer. Dis Esophagus. 2:365–371. 2007. View Article : Google Scholar | |
Rohtagi P, Swisher SG, Correa AM, et al: Characterization of pathologic complete response after preoperative chemoradiotherapy in carcinoma of the esophagus and outcome after pathologic complete response. Cancer. 104:2365–2372. 2005. View Article : Google Scholar : PubMed/NCBI | |
Donahue JM, Nichols FC, Li Z, et al: Complete pathological response after neoadjuvant chemoradiotherapy for esophageal cancer is associated with enhanced survival. Ann Thorac Surg. 87:392–399. 2009. View Article : Google Scholar : PubMed/NCBI | |
Vallbohmer D and Lenz HJ: Predictive and prognostic molecular markers in outcome of esophageal cancer. Dis Esophagus. 19:425–432. 2006. View Article : Google Scholar : PubMed/NCBI | |
Luthra R, Wu TT, Luthra MG, et al: Gene expression profiling of localized esophageal carcinomas: association with pathologic response to preoperative chemoradiation. J Clin Oncol. 24:259–267. 2006. View Article : Google Scholar : PubMed/NCBI | |
Lee JL, Park SI, Kim SB, et al: A single institutional phase III trial of preoperative chemotherapy with hyperfractionation radiotherapy plus surgery vs. surgery alone for resectable esophageal squamous cell carcinoma. Ann Oncol. 15:947–954. 2004. View Article : Google Scholar | |
Tepper J, Krasna MJ, Niedzwiecki D, et al: Phase III trial of trimodality therapy with cisplatin, fluorouracil, radiotherapy, and surgery compared with surgery alone for esophageal cancer: CALGB 9781. J Clin Oncol. 26:1086–1092. 2008. View Article : Google Scholar : PubMed/NCBI | |
Kaklamanos IG, Walker GR, Ferry K, et al: Neoadjuvant treatment for resectable cancer of the esophagusand the gastroesophageal junction: a meta-analysis of randomized clinical trials. Ann Surg Oncol. 10:754–761. 2003. View Article : Google Scholar : PubMed/NCBI | |
Fiorica F, Di Bona D, Schepis F, et al: Preoperative chemoradiotherapy for oesophageal cancer: a systematic review and meta-analysis. Gut. 53:925–930. 2004. View Article : Google Scholar : PubMed/NCBI | |
Greer SE, Goodney PP, Sutton JE and Birkmeyer JD: Neoadjuvant chemoradiotherapy for esophageal carcinoma: A meta-analysis. Surgery. 137:172–177. 2005. View Article : Google Scholar : PubMed/NCBI | |
Graham AJ, Shrive FM, Ghali WA, et al: Defining the optimal treatment of locally advanced esophageal cancer: a systematic review and decision analysis. Ann Toracic Surg. 83:1257–1264. 2007. View Article : Google Scholar : PubMed/NCBI | |
Lv J, Cao XF, Zhu B, et al: Effect of neoadjuvant chemoradiotherapy on prognosis and surgery for esophageal carcinoma. World J Gastroenterol. 15:4962–4968. 2009. View Article : Google Scholar : PubMed/NCBI |