Cells of origin of squamous epithelium, dysplasia and cancer in the head and neck region after bone marrow transplantation

Kano,Yoshihiro; Ishii,Hideshi; Konno,Masamitsu; Yamasaki,Makoto; Miyata,Hiroshi; Nishikawa,Shimpei; Hamabe,Atsushi; Ogawa,Hisataka; Takahashi,Hidekazu; Ohta,Katsuya; Hasegawa,Shinichiro; Tanaka,Kouji; Fukusumi,Takahito; Otsuka,Masahisa; Kawamoto,Koichi; Haraguchi,Naotsugu; Fujimoto,Rika; Isobe,Masaharu; Tomita,Yasuhiko; Matsuura,Nariaki; Takiguchi,Shuji; Mori,Masaki; Doki,Yuichiro

doi:10.3892/ijo.2013.2206

Cells of origin of squamous epithelium, dysplasia and cancer in the head and neck region after bone marrow transplantation

Authors:
- Yoshihiro Kano
- Hideshi Ishii
- Masamitsu Konno
- Makoto Yamasaki
- Hiroshi Miyata
- Shimpei Nishikawa
- Atsushi Hamabe
- Hisataka Ogawa
- Hidekazu Takahashi
- Katsuya Ohta
- Shinichiro Hasegawa
- Kouji Tanaka
- Takahito Fukusumi
- Masahisa Otsuka
- Koichi Kawamoto
- Naotsugu Haraguchi
- Rika Fujimoto
- Masaharu Isobe
- Yasuhiko Tomita
- Nariaki Matsuura
- Shuji Takiguchi
- Masaki Mori
- Yuichiro Doki
View Affiliations

Affiliations: Department of Frontier Science for Cancer and Chemotherapy, Osaka University, Graduate School of Medicine, Osaka, Japan, Department of Gastroenterological Surgery, Osaka University, Graduate School of Medicine, Osaka, Japan, Laboratory of Molecular and Cellular Biology, Department of Materials and Biosystem Engineering, Faculty of Engineering, Toyama University, Toyama, Japan, Department of Pathology, Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka, Japan, Department of Functional Diagnostic Science, Osaka University, Graduate School of Medicine, Osaka, Japan
Published online on: December 3, 2013 https://doi.org/10.3892/ijo.2013.2206
Pages: 443-450

Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )

Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )

Cited By (CrossRef): 0 citations Loading Articles...

Abstract

Secondary solid tumors that occur after hematopoietic stem cell transplantation (HSCT) are late complications of HSCT. Previously, secondary solid tumors were considered to be recipient-derived cells because transplanted cells do not contain epithelial cells. Recently, however, not only donor‑derived epithelial cells but also donor-derived secondary solid tumors have also been reported in mice and humans. It means that circulating bone marrow-derived stem cells (BMDCs) including hematopoietic stem cells include the stem cells of many tissue types and the precancerous cells of many solid tumors. In most reports of donor-derived secondary solid tumors, however, tumors contained a low proportion of BMDC-derived epithelial cells in mixed solid tumor tissues. To our knowledge, there are only five known cases of completely donor-derived tumor tissues, i.e., four oral SCCs and a pharyngeal SCC. In this study, we analyzed five human clinical samples of solid tumors, i.e., two esophageal squamous cell carcinomas (SCCs), two oral SCCs and a tongue carcinoma. In the oral and tongue, completely donor-derived tissues were not observed, but in esophagus a completely donor-derived esophageal epidermis and SCC were observed for the first time. In addition, in another esophageal SCC patient, a completely donor-derived dysplasia region of esophageal epidermis was observed near recipient-derived SCC. This study suggests that BMDC-derived cells include the stem cells of esophageal epidermis and the precancerous cells of esophageal SCC and can differentiate into esophageal epithelium and esophageal SCC.

View Figures

View References

1.	Konno M, Hamabe A, Hasegawa O, et al: Adipose-derived mesenchymal stem cells and regenerative medicine. Dev Growth Differ. 55:309–318. 2013. View Article : Google Scholar : PubMed/NCBI
2.	Puetzer JL, Petitte JN and Loboa EG: Comparative review of growth factors for induction of three-dimensional in vitro chondrogenesis in human mesenchymal stem cells isolated from bone marrow and adipose tissue. Tissue Eng Part B Rev. 16:435–444. 2010. View Article : Google Scholar : PubMed/NCBI
3.	Varon C, Dubus P, Mazurier F, et al: Helicobacter pylori infection recruits bone marrow-derived cells that participate in gastric preneoplasia in mice. Gastroenterology. 142:281–291. 2012. View Article : Google Scholar
4.	Sung AD and Chao NJ: Concise review: acute graft-versus-host disease: immunobiology, prevention, and treatment. Stem Cells Transl Med. 2:25–32. 2013. View Article : Google Scholar : PubMed/NCBI
5.	Ohtani N and Hara E: Roles and mechanisms of cellular senescence in regulation of tissue homeostasis. Cancer Sci. 104:525–530. 2013. View Article : Google Scholar : PubMed/NCBI
6.	Du K, Hu Y, Wu K and Huang H: Long-term outcomes of antithymocyte globulin in patients with hematological malignancies undergoing myeloablative allogeneic hematopoietic cell transplantation: a systematic review and meta-analysis. Clin Transplant. 27:E91–E100. 2013. View Article : Google Scholar
7.	Chao YH, Wu HP, Chan CK, et al: Umbilical cord-derived mesenchymal stem cells for hematopoietic stem cell transplantation. J Biomed Biotechnol. 2012:7595032012.PubMed/NCBI
8.	Bernardo ME, Cometa AM and Locatelli F: Mesenchymal stromal cells: a novel and effective strategy for facilitating engraftment and accelerating hematopoietic recovery after transplantation? Bone Marrow Transplant. 47:323–329. 2012. View Article : Google Scholar
9.	Majhail NS: Secondary cancers following allogeneic haematopoietic cell transplantation in adults. Br J Haematol. 154:301–310. 2010. View Article : Google Scholar : PubMed/NCBI
10.	Arwert EN, Hoste E and Watt FM: Epithelial stem cells, wound healing and cancer. Nat Rev Cancer. 12:170–180. 2012. View Article : Google Scholar : PubMed/NCBI
11.	Houghton J, Stoicov C, Nomura S, et al: Gastric cancer originating from bone marrow-derived cells. Science. 306:1568–1571. 2004. View Article : Google Scholar : PubMed/NCBI
12.	Jenkins RB, Qian J, Lieber MM, et al: Detection of c-myc oncogene amplification and chromosomal anomalies in metastatic prostatic carcinoma by fluorescence in situ hybridization. Cancer Res. 57:524–531. 1997.PubMed/NCBI
13.	Krause DS, Theise ND, Collector MI, et al: Multi-organ, multi-lineage engraftment by a single bone marrow-derived stem cell. Cell. 105:369–377. 2001. View Article : Google Scholar : PubMed/NCBI
14.	Rizvi AZ, Swain JR, Davies PS, et al: Bone marrow-derived cells fuse with normal and transformed intestinal stem cells. Proc Natl Acad Sci USA. 103:6321–6325. 2006. View Article : Google Scholar : PubMed/NCBI
15.	Inokuma D, Abe R, Fujita Y, et al: CTACK/CCL27 accelerates skin regeneration via accumulation of bone marrow-derived keratinocytes. Stem Cells. 24:2810–2816. 2006. View Article : Google Scholar : PubMed/NCBI
16.	Okumura T, Wang SS, Takaishi S, et al: Identification of a bone marrow-derived mesenchymal progenitor cell subset that can contribute to the gastric epithelium. Lab Invest. 89:1410–1422. 2009. View Article : Google Scholar : PubMed/NCBI
17.	Scarlett CJ, Colvin EK, Pinese M, et al: Recruitment and activation of pancreatic stellate cells from the bone marrow in pancreatic cancer: a model of tumor-host interaction. PLoS One. 6:e260882011. View Article : Google Scholar : PubMed/NCBI
18.	Matsumoto T, Okamoto R, Yajima T, et al: Increase of bone marrow-derived secretory lineage epithelial cells during regeneration in the human intestine. Gastroenterology. 128:1851–1867. 2005. View Article : Google Scholar : PubMed/NCBI
19.	Tran SD, Pillemer SR, Dutra A, et al: Differentiation of human bone marrow-derived cells into buccal epithelial cells in vivo: a molecular analytical study. Lancet. 361:1084–1088. 2003. View Article : Google Scholar : PubMed/NCBI
20.	Mattsson J, Jansson M, Wernerson A, et al: Lung epithelial cells and type II pneumocytes of donor origin after allogeneic hematopoietic stem cell transplantation. Transplantation. 78:154–157. 2004. View Article : Google Scholar : PubMed/NCBI
21.	Körbling M, Katz RL, Khanna A, et al: Hepatocytes and epithelial cells of donor origin in recipients of peripheral-blood stem cells. N Engl J Med. 346:738–746. 2002.PubMed/NCBI
22.	Miura M, Miura Y, Padilla-Nash HM, et al: Accumulated chromosomal instability in murine bone marrow mesenchymal stem cells leads to malignant transformation. Stem Cells. 24:1095–1103. 2006. View Article : Google Scholar : PubMed/NCBI
23.	Li HC, Stoicov C, Rogers AB and Houghton J: Stem cells and cancer: evidence for bone marrow stem cells in epithelial cancers. World J Gastroenterol. 12:363–371. 2006.PubMed/NCBI
24.	Liu C, Chen Z, Chen Z, et al: Multiple tumor types may originate from bone marrow-derived cells. Neoplasia. 8:716–724. 2006. View Article : Google Scholar : PubMed/NCBI
25.	Guest I, Ilic Z, Ma J, Grant D, et al: Direct and indirect contribution of bone marrow-derived cells to cancer. Int J Cancer. 126:2308–2318. 2010.PubMed/NCBI
26.	Cogle CR, Theise ND, Fu D, et al: Bone marrow contributes to epithelial cancers in mice and humans as developmental mimicry. Stem Cells. 25:1881–1887. 2007. View Article : Google Scholar : PubMed/NCBI
27.	Avital I, Moreira AL, Klimstra DS, et al: Donor-derived human bone marrow cells contribute to solid organ cancers developing after bone marrow transplantation. Stem Cells. 25:2903–2909. 2007. View Article : Google Scholar
28.	Soldini D, Moreno E, Martin V, et al: BM-derived cells randomly contribute to neoplastic and non-neoplastic epithelial tissues at low rates. Bone Marrow Transplant. 42:749–755. 2008. View Article : Google Scholar : PubMed/NCBI
29.	Janin A, Murata H, Leboeuf C, et al: Donor-derived oral squamous cell carcinoma after allogeneic bone marrow transplantation. Blood. 113:1834–1840. 2009. View Article : Google Scholar : PubMed/NCBI
30.	Hutchinson L, Stenstrom B, Chen D, et al: Human Barrett’s adenocarcinoma of the esophagus, associated myofibroblasts, and endothelium can arise from bone marrow-derived cells after allogeneic stem cell transplant. Stem Cells Dev. 20:11–17. 2011.
31.	Munakata W, Nomoto J, Takahashi N, et al: Carcinoma of donor origin after allogeneic peripheral blood stem cell transplantation. Am J Surg Pathol. 36:1376–1384. 2012. View Article : Google Scholar : PubMed/NCBI