Downregulation of FoxM1 inhibits proliferation, invasion and angiogenesis of HeLa cells in vitro and in vivo

  • Authors:
    • Hong Chen
    • Yang Zou
    • Hong Yang
    • Jingjing Wang
    • Hong Pan
  • View Affiliations

  • Published online on: September 9, 2014     https://doi.org/10.3892/ijo.2014.2645
  • Pages: 2355-2364
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Abstract

FoxM1 is a specific transcription factor that has an important function in aggressive human carcinomas, including cervical cancer. However, the specific function and internal molecular mechanism in cervical cancer remain unclear. In this study, RNAi-mediated FoxM1 knockdown inhibited cell growth. This process also decreased the migration and invasion activities of HeLa cells in vitro. Downregulation of FoxM1 inhibited tumor growth and angiogenesis in vivo. In addition, the expressions of uPA, matrix metalloproteinase (MMP)-2, MMP-9 and VEGF were significantly decreased in vitro and in vivo. These results suggested that the inactivation of FoxM1 could be a novel therapeutic target for cervical cancer treatment.
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December-2014
Volume 45 Issue 6

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Spandidos Publications style
Chen H, Zou Y, Yang H, Wang J and Pan H: Downregulation of FoxM1 inhibits proliferation, invasion and angiogenesis of HeLa cells in vitro and in vivo. Int J Oncol 45: 2355-2364, 2014.
APA
Chen, H., Zou, Y., Yang, H., Wang, J., & Pan, H. (2014). Downregulation of FoxM1 inhibits proliferation, invasion and angiogenesis of HeLa cells in vitro and in vivo. International Journal of Oncology, 45, 2355-2364. https://doi.org/10.3892/ijo.2014.2645
MLA
Chen, H., Zou, Y., Yang, H., Wang, J., Pan, H."Downregulation of FoxM1 inhibits proliferation, invasion and angiogenesis of HeLa cells in vitro and in vivo". International Journal of Oncology 45.6 (2014): 2355-2364.
Chicago
Chen, H., Zou, Y., Yang, H., Wang, J., Pan, H."Downregulation of FoxM1 inhibits proliferation, invasion and angiogenesis of HeLa cells in vitro and in vivo". International Journal of Oncology 45, no. 6 (2014): 2355-2364. https://doi.org/10.3892/ijo.2014.2645