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The value of trefoil factor 3 expression in predicting the long‑term outcome and early recurrence of colorectal cancer

  • Authors:
    • Kiyoto Morito
    • Jun Nakamura
    • Yoshihiko Kitajima
    • Keita Kai
    • Tomokazu Tanaka
    • Hiroshi Kubo
    • Shuusuke Miyake
    • Hirokazu Noshiro

  • View Affiliations

  • Published online on: November 17, 2014     https://doi.org/10.3892/ijo.2014.2755
  • Pages: 563-568
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Abstract

The trefoil factor (TFF) family comprises three thermo-stable and protease-resistant proteins (TFF1, TFF2 and TFF3) and plays an essential role in gastrointestinal mucosa protection and regeneration, and TFFs have recently been found to be involved in the development and progression of various types of cancer. However, the clinical significance of TFFs in colorectal cancer (CRC) patients remains unclear. The present study determined the relationship between TFF expression and clinicopathological findings, as well as long-term outcome in CRC patients. The mRNA expression levels of TFFs were examined in the excised CRC specimens obtained from 154 consecutive CRC patients who underwent surgical resection between 2005 and 2007 at our institution. TFF3 expression was significantly associated with the presence of distant metastasis (p=0.017), although neither TFF1 nor TFF2 expression was associated with the clinicopathological features. Survival rate of the patients with positive TFF3 was significantly worse compared to those with negative TFF3 (p=0.011). A multivariate analysis revealed that the expression of TFF3, lymph node metastasis, and vascular invasion were independent prognostic factors for disease-specific survival. Furthermore, among 134 patients with no clinical findings of metastasis at surgery, the patients with positive TFF3 experienced recurrence within one year more frequently than those with negative TFF3 (p=0.039). In conclusion, TFF3 is not only a useful biomarker for a long-term surgical result in CRC patient, but also may be a risk factor of early recurrence.
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February-2015
Volume 46 Issue 2

Print ISSN: 1019-6439
Online ISSN:1791-2423

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  • Source Normalized Impact per Paper (SNIP): 0.88
  • SCImago Journal Rank (SJR): 1.099
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Spandidos Publications style
Morito K, Nakamura J, Kitajima Y, Kai K, Tanaka T, Kubo H, Miyake S and Noshiro H: The value of trefoil factor 3 expression in predicting the long‑term outcome and early recurrence of colorectal cancer. Int J Oncol 46: 563-568, 2015.
APA
Morito, K., Nakamura, J., Kitajima, Y., Kai, K., Tanaka, T., Kubo, H. ... Noshiro, H. (2015). The value of trefoil factor 3 expression in predicting the long‑term outcome and early recurrence of colorectal cancer. International Journal of Oncology, 46, 563-568. https://doi.org/10.3892/ijo.2014.2755
MLA
Morito, K., Nakamura, J., Kitajima, Y., Kai, K., Tanaka, T., Kubo, H., Miyake, S., Noshiro, H."The value of trefoil factor 3 expression in predicting the long‑term outcome and early recurrence of colorectal cancer". International Journal of Oncology 46.2 (2015): 563-568.
Chicago
Morito, K., Nakamura, J., Kitajima, Y., Kai, K., Tanaka, T., Kubo, H., Miyake, S., Noshiro, H."The value of trefoil factor 3 expression in predicting the long‑term outcome and early recurrence of colorectal cancer". International Journal of Oncology 46, no. 2 (2015): 563-568. https://doi.org/10.3892/ijo.2014.2755