An accurate prognostic staging system for hepatocellular carcinoma patients after curative hepatectomy

Tokumitsu,Yukio; Tamesa,Takao; Matsukuma,Satoshi; Hashimoto,Noriaki; Maeda,Yoshinari; Tokuhisa,Yoshihiro; Sakamoto,Kazuhiko; Ueno,Tomio; Hazama,Shoichi; Ogihara,Hiroyuki; Fujita,Yusuke; Hamamoto,Yoshihiko; Oka,Masaaki; Iizuka,Norio

doi:10.3892/ijo.2014.2798

An accurate prognostic staging system for hepatocellular carcinoma patients after curative hepatectomy

Authors:
- Yukio Tokumitsu
- Takao Tamesa
- Satoshi Matsukuma
- Noriaki Hashimoto
- Yoshinari Maeda
- Yoshihiro Tokuhisa
- Kazuhiko Sakamoto
- Tomio Ueno
- Shoichi Hazama
- Hiroyuki Ogihara
- Yusuke Fujita
- Yoshihiko Hamamoto
- Masaaki Oka
- Norio Iizuka
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Affiliations: Department of Digestive Surgery and Surgical Oncology, Yamaguchi University Graduate School of Medicine, Yamaguchi, Japan, Department of Biomolecular Engineering Applied Molecular Bioscience, Yamaguchi University Graduate School of Medicine, Yamaguchi, Japan, Yamaguchi University, Yamaguchi, Japan
Published online on: December 17, 2014 https://doi.org/10.3892/ijo.2014.2798
Pages: 944-952
Copyright: © Tokumitsu et al. This is an open access article distributed under the terms of Creative Commons Attribution License [CC BY_NC 3.0].

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Abstract

The aim of this study was to develop an accurate predictive system for prognosis of hepatocellular carcinoma (HCC) patients after hepatectomy. We pooled data of clinicopathological features of 234 HCC patients who underwent curative hepatectomy. On the basis of the pooled data, we established a simple predictive staging system (PS score) scored by the mathematical product of tumor number and size, and degree of liver function. We compared the prognostic abilities of the PS score (score 0-3) with those of six well-known clinical staging systems. Then, we found that there were significant differences (P<0.05) in both disease-free survival (DFS) and overall survival (OS) between patients with different PS scores (PS score 0 vs. 1; PS score 1 vs. 2), and there was a significant difference in DFS, but not OS, between patients with PS score 2 and those with PS score 3. Moreover, the PS score had smaller values of the Akaike information criterion for both DFS and OS than any of the six well-known clinical staging systems. These results suggest that the PS score serves as a simple, accurate predictor for the prognosis of HCC patients after hepatectomy.

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