miRNA-1207-5p is associated with cancer progression by targeting stomatin-like protein 2 in esophageal carcinoma Corrigendum in /10.3892/ijo.2018.4254 Retraction in /10.3892/ijo.2022.5470

Yang,Xuan; Zang,Wenqiao; Xuan,Xiaoyan; Wang,Zhongquan; Liu,Zhicai; Wang,Jinwu; Cui,Jing; Zhao,Guoqiang

doi:10.3892/ijo.2015.2900

miRNA-1207-5p is associated with cancer progression by targeting stomatin-like protein 2 in esophageal carcinoma Corrigendum in /10.3892/ijo.2018.4254

Retraction in: /10.3892/ijo.2022.5470

miRNA-1207-5p is associated with cancer progression by targeting stomatin-like protein 2 in esophageal carcinoma

Corrigendum in: /10.3892/ijo.2018.4254 Retraction in /10.3892/ijo.2022.5470

Authors:
- Xuan Yang
- Wenqiao Zang
- Xiaoyan Xuan
- Zhongquan Wang
- Zhicai Liu
- Jinwu Wang
- Jing Cui
- Guoqiang Zhao
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Affiliations: College of Basic Medical Sciences, Zhengzhou University, Zhengzhou 450001, P.R. China, Tumor Hospital of Linzhou City, Linzhou, Henan 456500, P.R. China
Published online on: February 19, 2015 https://doi.org/10.3892/ijo.2015.2900
Pages: 2163-2171

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Abstract

Newly discovered intrinsic regulators, the miRNAs regulate gene expression by binding to the 3'-untranslated regions of the genome. Accumulating studies have indicated that miRNAs are aberrantly expressed in various human cancers. We found that miRNA-1207-5p (miR‑1207-5p) was markedly downregulated in esophageal carcinoma (EC) tissues, and was correlated with EC differentiation, pathological stage and lymph node metastasis. Rates of apoptosis were increased and cell invasion ability was decreased in EC9706 and EC-1 cells transfected with a miR‑1207-5p mimic. Stomatin-like protein 2 (STOML-2) was predicted to be a potential target of miR‑1207-5p by bioinformatics analysis and this was confirmed by luciferase assay and western blotting. Our study showed that STOML-2 was negatively regulated by miR‑1207-5p. Furthermore, overexpression of STOML-2 abolished the miR‑1207-5p anti-invasion function. Based on these results, we proposed that miR‑1207-5p might act as a potential therapeutic target in the treatment of EC.

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