Knockdown of metadherin inhibits angiogenesis in breast cancer

  • Authors:
    • Yan Liu
    • Xiangnan Kong
    • Xiaoyan Li
    • Baojiang Li
    • Qifeng Yang
  • View Affiliations

  • Published online on: April 20, 2015     https://doi.org/10.3892/ijo.2015.2973
  • Pages: 2459-2466
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Abstract

Angiogenesis plays an important role in cancer growth, invasion and metastasis. It has been confirmed that metadherin (MTDH) is associated with angiogenesis. However, the detailed mechanism of MTDH on angiogenesis has not yet been reported. In this study, we demonstrate the anti-angiogenic function of MTDH in breast cancer. With RNA interference strategies, we found that knockdown of MTDH inhibits cellular angiogenesis both in vitro and ex vivo. Furthermore, we revealed that ERK1/2 pathway is involved in the anti-angiogenic function of MTDH, and the function can be partially reversed via upregulation of microRNA-21 (miR-21). In conclusion, knockdown of MTDH can inhibit angiogenesis in breast cancer. These results show that MTDH is a viable therapeutic target for anti-angiogenesis in breast cancer.
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June-2015
Volume 46 Issue 6

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Copy and paste a formatted citation
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Spandidos Publications style
Liu Y, Kong X, Li X, Li B and Yang Q: Knockdown of metadherin inhibits angiogenesis in breast cancer. Int J Oncol 46: 2459-2466, 2015.
APA
Liu, Y., Kong, X., Li, X., Li, B., & Yang, Q. (2015). Knockdown of metadherin inhibits angiogenesis in breast cancer. International Journal of Oncology, 46, 2459-2466. https://doi.org/10.3892/ijo.2015.2973
MLA
Liu, Y., Kong, X., Li, X., Li, B., Yang, Q."Knockdown of metadherin inhibits angiogenesis in breast cancer". International Journal of Oncology 46.6 (2015): 2459-2466.
Chicago
Liu, Y., Kong, X., Li, X., Li, B., Yang, Q."Knockdown of metadherin inhibits angiogenesis in breast cancer". International Journal of Oncology 46, no. 6 (2015): 2459-2466. https://doi.org/10.3892/ijo.2015.2973