The NF-κB subunit RelB regulates the migration and invasion abilities and the radio-sensitivity of prostate cancer cells

  • Authors:
    • Jie Wang
    • Suqin Yi
    • Jun Zhou
    • Youtao Zhang
    • Feng Guo
  • View Affiliations

  • Published online on: April 25, 2016     https://doi.org/10.3892/ijo.2016.3500
  • Pages: 381-392
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Abstract

NF-κB subunits play important roles in carcinogenesis of a variety of human malignancies and response to cancer therapy; however, the contribution of an individual subunit has not been thoroughly defined. Constitutive activation of the canonical NF-κB subunit is a critical event in prostate carcinogenesis. Recent findings point out that RelB, which contributes to the non-canonical NF-κB activity, functions importantly in the prostate cancer progression. Here, we investigated systemically the functional roles of RelB in prostate cancer and examine its significance as a therapeutic target. Targeting RelB using short hairpin RNA approach in androgen-independent DU145 prostate cancer cells interfered with various biological behaviors of cells. We observed that RelB knockdown inhibited prostate cancer cell growth, migration, and invasion, and enhanced proteasome inhibitor sensitivity. The altered expression of anti-apoptotic gene Bcl-2 played critical roles in regulating both spontaneous and radiation-induced apoptosis in the presence of RelB knockdown. For the first time, we showed that RelB knockdown significantly attenuated the migration and invasion of DU145 prostate cancer cells, due to the reduction of integrin β-1. Collectively, we provided evidence that RelB functioned as an oncogene in prostate cancer. Developing a RelB-targeted therapeutic intervention, is valuable in treating advanced, metastatic prostate cancer.
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July-2016
Volume 49 Issue 1

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Spandidos Publications style
Wang J, Yi S, Zhou J, Zhang Y and Guo F: The NF-κB subunit RelB regulates the migration and invasion abilities and the radio-sensitivity of prostate cancer cells. Int J Oncol 49: 381-392, 2016
APA
Wang, J., Yi, S., Zhou, J., Zhang, Y., & Guo, F. (2016). The NF-κB subunit RelB regulates the migration and invasion abilities and the radio-sensitivity of prostate cancer cells. International Journal of Oncology, 49, 381-392. https://doi.org/10.3892/ijo.2016.3500
MLA
Wang, J., Yi, S., Zhou, J., Zhang, Y., Guo, F."The NF-κB subunit RelB regulates the migration and invasion abilities and the radio-sensitivity of prostate cancer cells". International Journal of Oncology 49.1 (2016): 381-392.
Chicago
Wang, J., Yi, S., Zhou, J., Zhang, Y., Guo, F."The NF-κB subunit RelB regulates the migration and invasion abilities and the radio-sensitivity of prostate cancer cells". International Journal of Oncology 49, no. 1 (2016): 381-392. https://doi.org/10.3892/ijo.2016.3500