Kinesin family members KIF11 and KIF23 as potential therapeutic targets in malignant pleural mesothelioma

  • Authors:
    • Tatsuya Kato
    • Daiyoon Lee
    • Licun Wu
    • Priya Patel
    • Ahn Jin Young
    • Hironobu Wada
    • Hsin-Pei Hu
    • Hideki Ujiie
    • Mitsuhito Kaji
    • Satoshi Kano
    • Shinichi Matsuge
    • Hiromitsu Domen
    • Kichizo Kaga
    • Yoshiro Matsui
    • Hiromi Kanno
    • Yutaka Hatanaka
    • Kanako C. Hatanaka
    • Yoshihiro Matsuno
    • Marc de Perrot
    • Kazuhiro Yasufuku
  • View Affiliations

  • Published online on: June 7, 2016     https://doi.org/10.3892/ijo.2016.3566
  • Pages: 448-456
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Abstract

Malignant pleural mesothelioma (MPM) is a rare and aggressive form of cancer commonly associated with asbestos exposure that stems from the thoracic mesothelium with high mortality rate. Currently, treatment options for MPM are limited, and new molecular targets for treatments are urgently needed. Using quantitative reverse transcription-polymerase chain reaction (RT-PCR) and an RNA interference-based screening, we screened two kinesin family members as potential therapeutic targets for MPM. Following in vitro investigation of the target silencing effects on MPM cells, a total of 53 MPMs were analyzed immunohistochemically with tissue microarray. KIF11 and KIF23 transcripts were found to be overexpressed in the majority of clinical MPM samples as well as human MPM cell lines as determined by quantitative RT-PCR. Gene knockdown in MPM cell lines identified growth inhibition following knockdown of KIF11 and KIF23. High expression of KIF11 (KIF11-H) and KIF23 (KIF23-H) were found in 43.4 and 50.9% of all the MPM cases, respectively. Patients who received curative resection with tumors displaying KIF23-H showed shorter overall survival (P=0.0194). These results provide that inhibition of KIF11 and KIF23 may hold promise for treatment of MPMs, raising the possibility that kinesin-based drug targets may be developed in the future.
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August-2016
Volume 49 Issue 2

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Spandidos Publications style
Kato T, Lee D, Wu L, Patel P, Young AJ, Wada H, Hu H, Ujiie H, Kaji M, Kano S, Kano S, et al: Kinesin family members KIF11 and KIF23 as potential therapeutic targets in malignant pleural mesothelioma. Int J Oncol 49: 448-456, 2016.
APA
Kato, T., Lee, D., Wu, L., Patel, P., Young, A.J., Wada, H. ... Yasufuku, K. (2016). Kinesin family members KIF11 and KIF23 as potential therapeutic targets in malignant pleural mesothelioma. International Journal of Oncology, 49, 448-456. https://doi.org/10.3892/ijo.2016.3566
MLA
Kato, T., Lee, D., Wu, L., Patel, P., Young, A. J., Wada, H., Hu, H., Ujiie, H., Kaji, M., Kano, S., Matsuge, S., Domen, H., Kaga, K., Matsui, Y., Kanno, H., Hatanaka, Y., Hatanaka, K. C., Matsuno, Y., de Perrot, M., Yasufuku, K."Kinesin family members KIF11 and KIF23 as potential therapeutic targets in malignant pleural mesothelioma". International Journal of Oncology 49.2 (2016): 448-456.
Chicago
Kato, T., Lee, D., Wu, L., Patel, P., Young, A. J., Wada, H., Hu, H., Ujiie, H., Kaji, M., Kano, S., Matsuge, S., Domen, H., Kaga, K., Matsui, Y., Kanno, H., Hatanaka, Y., Hatanaka, K. C., Matsuno, Y., de Perrot, M., Yasufuku, K."Kinesin family members KIF11 and KIF23 as potential therapeutic targets in malignant pleural mesothelioma". International Journal of Oncology 49, no. 2 (2016): 448-456. https://doi.org/10.3892/ijo.2016.3566