Expression and function of PIM kinases in osteosarcoma

Retraction in: /10.3892/ijo.2023.5577

  • Authors:
    • Shuai Mou
    • Guangbin Wang
    • Ding Ding
    • Dongdong Yu
    • Yi Pei
    • Songling Teng
    • Qin Fu
  • View Affiliations

  • Published online on: September 26, 2016     https://doi.org/10.3892/ijo.2016.3708
  • Pages: 2116-2126
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Abstract

The provirus integrating site Moloney murine leukemia virus (PIM) family of serine/threonine protein kinases is composed of three members, PIM1, PIM2 and PIM3, which have been identified as oncoproteins in various malignancies. However, their role in osteosarcoma (OS) remains largely unknown. This study aimed to examine the expression patterns and the clinical significance of PIM kinases in human OS and their biological effects in human OS cell lines. Immunohistochemical staining was used to detect PIM kinases in archived pathologic material from 43 patients with primary OS; in addition, the effects of PIM knockdown and overexpression on the proliferation, migration and invasion of OS cell lines were determined. We observed that all three PIM kinases were frequently expressed in OS, but only PIM1 positive expression was associated with poorer prognosis regarding overall survival of OS patients. In addition, knockdown of PIM kinases notably inhibited OS cell proliferation, migration and invasiveness, whereas overexpression of PIM kinases resulted in increased OS cell growth and motility. This study suggests that PIM1 could be a valuable prognostic marker in patients with OS, and the biological functions of PIM kinase family in the osteosarcoma cell lines indicate that they could serve as potential therapeutic targets for OS.
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November-2016
Volume 49 Issue 5

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Spandidos Publications style
Mou S, Wang G, Ding D, Yu D, Pei Y, Teng S and Fu Q: Expression and function of PIM kinases in osteosarcoma Retraction in /10.3892/ijo.2023.5577. Int J Oncol 49: 2116-2126, 2016.
APA
Mou, S., Wang, G., Ding, D., Yu, D., Pei, Y., Teng, S., & Fu, Q. (2016). Expression and function of PIM kinases in osteosarcoma Retraction in /10.3892/ijo.2023.5577. International Journal of Oncology, 49, 2116-2126. https://doi.org/10.3892/ijo.2016.3708
MLA
Mou, S., Wang, G., Ding, D., Yu, D., Pei, Y., Teng, S., Fu, Q."Expression and function of PIM kinases in osteosarcoma Retraction in /10.3892/ijo.2023.5577". International Journal of Oncology 49.5 (2016): 2116-2126.
Chicago
Mou, S., Wang, G., Ding, D., Yu, D., Pei, Y., Teng, S., Fu, Q."Expression and function of PIM kinases in osteosarcoma Retraction in /10.3892/ijo.2023.5577". International Journal of Oncology 49, no. 5 (2016): 2116-2126. https://doi.org/10.3892/ijo.2016.3708