Effective PI3K modulators for improved therapy against malignant tumors and for neuroprotection of brain damage after tumor therapy (Review)

  • Authors:
    • Satoru Matsuda
    • Mayuko Ichimura
    • Mako Ogino
    • Noriko Nakano
    • Akari Minami
    • Toshiyuki Murai
    • Yasuko Kitagishi
  • View Affiliations

  • Published online on: September 27, 2016     https://doi.org/10.3892/ijo.2016.3710
  • Pages: 1785-1790
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Abstract

Due to the key role in various cellular processes including cell proliferation and cell survival on many cell types, dysregulation of the PI3K/AKT pathway represents a crucial step of the pathogenesis in many diseases. Furthermore, the tumor suppressor PTEN negatively regulates the PI3K/AKT pathway through its lipid phosphatase activity, which is recognized as one of the most frequently deleted and/or mutated genes in human cancer. Given the pervasive involvement of this pathway, the development of the molecules that modulate this PI3K/AKT signaling has been initiated in studies which focus on the extensive effective drug discovery. Consequently, the PI3K/AKT pathway appears to be an attractive pharmacological target both for cancer therapy and for neurological protection necessary after the therapy. A better understanding of the molecular relations could reveal new targets for treatment development. We review recent studies on the features of PI3K/AKT and PTEN, and their pleiotropic functions relevant to the signaling pathways involved in cancer progress and in neuronal damage by the therapy.
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November-2016
Volume 49 Issue 5

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Spandidos Publications style
Matsuda S, Ichimura M, Ogino M, Nakano N, Minami A, Murai T and Kitagishi Y: Effective PI3K modulators for improved therapy against malignant tumors and for neuroprotection of brain damage after tumor therapy (Review). Int J Oncol 49: 1785-1790, 2016.
APA
Matsuda, S., Ichimura, M., Ogino, M., Nakano, N., Minami, A., Murai, T., & Kitagishi, Y. (2016). Effective PI3K modulators for improved therapy against malignant tumors and for neuroprotection of brain damage after tumor therapy (Review). International Journal of Oncology, 49, 1785-1790. https://doi.org/10.3892/ijo.2016.3710
MLA
Matsuda, S., Ichimura, M., Ogino, M., Nakano, N., Minami, A., Murai, T., Kitagishi, Y."Effective PI3K modulators for improved therapy against malignant tumors and for neuroprotection of brain damage after tumor therapy (Review)". International Journal of Oncology 49.5 (2016): 1785-1790.
Chicago
Matsuda, S., Ichimura, M., Ogino, M., Nakano, N., Minami, A., Murai, T., Kitagishi, Y."Effective PI3K modulators for improved therapy against malignant tumors and for neuroprotection of brain damage after tumor therapy (Review)". International Journal of Oncology 49, no. 5 (2016): 1785-1790. https://doi.org/10.3892/ijo.2016.3710